期刊
LETTERS IN APPLIED MICROBIOLOGY
卷 74, 期 3, 页码 344-353出版社
OXFORD UNIV PRESS
DOI: 10.1111/lam.13617
关键词
16S rRNA gene sequencing; ALV-J infection; avian leukosis virus subgroup J; chicken; gut microbiota
资金
- Educational Commission of Guangdong Province, China [2018KTSCX217]
- Science and Technology Planning Project of Huizhou City, China [2019X0701012]
- International training project for outstanding young scientific research talents in Guangdong Universities
- Key Cultivation Program of Huizhou University [hzux1201623]
The study found that ALV-J infection alters the gut microbiota in chickens, disrupting the host-microbial homeostasis which may be involved in the pathogenesis of ALV-J infection.
Avian leukosis virus (ALV) poses a major threat to poultry. The chicken gut microbiota plays critical roles in host performance, health and immunity. However, the effect of viral infection on the microbiota of Chinese local chickens is not well understood. In this study, we performed high-throughput 16S rRNA gene sequencing and evaluated the gut microbiota profiles using faeces from ALV subgroup J (ALV-J)-infected and healthy Huiyang bearded chickens (Chinese local chickens). At the phylum level, ALV-J infection mainly increased the abundance of Bacteroidetes and Proteobacteria and decreased that of Firmicutes. An analysis at the order, family and genus levels showed that the abundance of Lactobacillales, Lactobacillaceae and Lactobacillus was the highest in normal chicken faeces, accounting for 89 center dot 07%, 86 center dot 47% and 86 center dot 46%, respectively, of phylotypes. Moreover, samples from ALV-J-infected chickens were enriched with Bacteroidales, Clostridiales, Bacteroidaceae, Ruminococcaceae, Lachnospiraceae and Bacteroides. Our findings highlight that ALV-J infection alters the gut microbiota and disrupts the host-microbial homeostasis in chickens, which may be involved in the pathogenesis of ALV-J infection.
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