期刊
INDIAN JOURNAL OF PHARMACEUTICAL EDUCATION AND RESEARCH
卷 50, 期 3, 页码 368-375出版社
ASSOC PHARMACEUTICAL TEACHERS INDIA
DOI: 10.5530/Ijper.50.3.8
关键词
Metabolic disorders; Obese; Aornia melanocarpa; Anthocyanin; Mechnism
资金
- Science and Technology Government Department Fund in Liaoning province [L2011008, UPRP20140428]
- Foundation of Ocean and fishery hall in Liaoning province [201407]
- Social Science fund plan in Liaoning province [L15BJY029]
- China National Natural Science Foundation of China
The aim of this study was to investigate the effects of Aornia melanocarpa anthocyanin (AMA) on symptoms of metabolic syndrome in obese mouse. AMA can reduce weight. Blood glucose and lipid metabolism were significantly improved, and so as hepatic lipid metabolism. This suggesting AMA is a strong indication of improved glucoselipid metabolism and weight. Moreover, both morphologic and histological detections indicated that AMA significantly reversed obsity induced hepatic steatosis and liver injury. Furthermore, AMA significantly ameliorated inflammatory cytokines including both IL-6 and TNF-alpha in liver and fatty tissue. Moreover, insulin receptor (IR), p-IRS and p-AKT that associated proteins about glucose-lipid metabolism signaling pathway were markedly up-regulated at protein levels by AMA. Our results demonstrate that Aornia melanocarpa anthocyanin treatment can alleviate obsity and metabolic syndrome. The beneficial effects of AMA are associated with improved glucose-lipid metabolism and reduced levels of inflammatory cytokines.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据