Amphiphilic Deep Eutectic Solvent Based on Lidocaine and Lauric Acid: Formation of Microemulsion and Gel

Deep eutectic solvent (DES), as a new type of promising green solvent, showed great advantages of easy preparation and no need for purification after synthesis and displayed great potential applications in various fields. Herein, we have constructed a new type of therapeutic DES based on lidocaine and lauric acid. The DES displayed good surface activity in constructing a nonaqueous microemulsion with 1,2-propanediol (PG) and isopropyl myristate (IPM) being the polar phase and nonpolar phase, respectively. The obtained nonaqueous microemulsion displayed a structural transition from W/O type to O/W type via a bicontinuous structure with an increase of the PG content. The size, morphology, and microstructure of the microemulsion were explored using dynamic light scattering (DLS), transmission electron microscopy (TEM), and UV-vis absorption spectra measurements. Furthermore, this novel DES can act as a gelator to form a gel in a certain water content range. The rheological measurements suggested the presence of a strong colloidal force. Therefore, the results presented herein were expected to provide a new perspective in the applications of deep eutectic solvent as a surfactant.

Automated summary

In this study, a therapeutic deep eutectic solvent (DES) based on lidocaine and lauric acid was constructed, and its applications in microemulsion and gel formation were explored. The results are expected to provide new insights into the use of deep eutectic solvents as surfactants.