期刊
LANCET ONCOLOGY
卷 22, 期 12, 页码 1787-1798出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/S1470-2045(21)00580-5
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-
类别
资金
- Intramural Research Program, Division of Cancer Epidemiology and Genetics, NIH
- Westat
- [HHSN261201800004C]
Li-Fraumeni syndrome is associated with significantly higher cancer incidence, especially in the childhood to 30 years age group. The probability of a first diagnosis of a non-breast cancer malignancy is substantially lower than that of any first cancer in female patients. Some individuals experience multiple cancers diagnosed within a short timeframe.
Background Li-Fraumeni syndrome, caused primarily by pathogenic or likely pathogenic germline TP53 variants, is a rare, variably penetrant, cancer predisposition syndrome with very high risks of cancer starting in childhood, including the risk of multiple primary malignancies over an individual's lifespan. We aimed to characterise and quantify cancer incidence, patterns, and genotype-phenotype associations in individuals with pathogenic or likely pathogenic germline TP53 variants. Methods This observational cohort study was done in 480 carriers of pathogenic or likely pathogenic germline TP53 variants enrolled in the National Cancer Institute's referral-based longitudinal Li-Fraumeni syndrome study between Aug 1, 2011, and March 24, 2020. Data on personal and family history of cancer were obtained through study questionnaires and validated by medical records. Variants were categorised on the basis of both loss-of-function (LOF) and dominant-negative effect (DNE) properties. Cancer incidence associated with Li-Fraumeni syndrome was compared with that of the general population using the Surveillance, Epidemiology, and End Results (SEER) 1975-2017 registry. Cancer incidence was evaluated with family-clustered Cox regression models and competing risk methods. This study is registered with ClinicalTrials.gov, NCT01443468. Findings Individuals with Li-Fraumeni syndrome had a nearly 24 times higher incidence of any cancer than the general population (standardised incidence ratio 23.9; 95% CI 21.9-26.0), with the highest comparative incidence from childhood to 30 years of age. The overall cancer incidence remained 10.3 (95% CI 7.9-13.2) times higher than that of the general population after age 50 years. In women, when considering breast cancer as a competing risk, the probability of a first diagnosis of a non-breast cancer malignancy was substantially lower than that of any first cancer (24.4% [95% CI 19.6-30.5] vs 50.4% [43.5-56.5] by age 33.7 years). Overall, DNE_LOF and notDNE_LOF variants were associated with earlier age at first and second cancer compared with notDNE_notLOF and DNE_notLOF variants. The time interval from first to second cancer was shorter among carriers whose first cancer diagnoses were later in life. Multiple cancers were diagnosed within a short timeframe in some individuals, regardless of the order of cancer occurrence. Interpretation This study adds granularity to the understanding of cancer incidence and patterns in individuals with pathogenic or likely pathogenic germline TP53 variants. Integration of age range-specific cancer incidence estimates, cancer-free survival by functional variant group, the potential impact of risk-reducing mastectomy on female cancer incidence, and data on subsequent malignancies will be important for the development of strategies to optimise cancer screening and management for these individuals. Copyright (C) 2021 Elsevier Ltd. All rights reserved.
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