Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study

Review Pediatrics

Susceptibility to SARS-CoV-2 Infection Among Children and Adolescents Compared With Adults A Systematic Review and Meta-analysis

Russell M. Viner et al.

Summary: This systematic review and meta-analysis found that children and adolescents have a 44% lower odds of secondary infection with SARS-CoV-2 compared to adults, with insufficient data to determine if children transmit the virus less than adults. Preliminary evidence suggests that children have a lower susceptibility to SARS-CoV-2 infection compared with adults, but their role in virus transmission remains unclear.

JAMA PEDIATRICS (2021)

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Review Immunology

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Setting-specific Transmission Rates: A Systematic Review and Meta-analysis

Hayley A. Thompson et al.

Summary: Households have the highest transmission rates for SARS-CoV-2, especially when exposure exceeds 5 days. Asymptomatic cases have approximately one-seventh the transmission potential of symptomatic cases, while presymptomatic cases have approximately two-thirds.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Medicine, General & Internal

BNT162b2 mRNA Covid-19 Vaccine in a Nationwide Mass Vaccination Setting

Noa Dagan et al.

Summary: A study conducted in Israel on nearly 600,000 individuals showed that the BNT162b2 mRNA vaccine was effective in reducing the risk of infection, hospitalization, and severe Covid-19. The effectiveness in preventing death was 72% during the period from day 14 through day 20 after the first dose, and hospitalization was reduced by 87% for the period 7 or more days after the second dose, similar to results from a randomized trial.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

Nasopharyngeal SARS-CoV-2 viral loads in young children do not differ significantly from those in older children and adults

Sharline Madera et al.

Summary: Current studies show that there is no significant difference in viral nucleic acid levels between young children and adults. This provides some insights for the safe reopening of schools.

SCIENTIFIC REPORTS (2021)

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Article Biochemistry & Molecular Biology

Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine

Matan Levine-Tiefenbrun et al.

Summary: COVID-19 vaccines not only provide protection to individual vaccinees, but may also reduce viral load in breakthrough infections, potentially leading to lower infectiousness and further suppressing virus spread.

NATURE MEDICINE (2021)

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Article Infectious Diseases

Vaccine effectiveness against infection with the Delta (B.1.617.2) variant, Norway, April to August 2021

Elina Seppala et al.

Summary: This population-based cohort study found that the vaccine effectiveness against the Delta variant was significantly lower for partially vaccinated individuals at 22.4% compared to 64.6% for fully vaccinated individuals, when compared to vaccine effectiveness against the Alpha variant at 54.5% and 84.4% respectively.

EUROSURVEILLANCE (2021)

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Letter Medicine, General & Internal

SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness

Aziz Sheikh et al.

LANCET (2021)

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Letter Medicine, General & Internal

Effect of Vaccination on Household Transmission of SARS-CoV-2 in England

Ross J. Harris et al.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Article Multidisciplinary Sciences

Estimating infectiousness throughout SARS-CoV-2 infection course

Terry C. Jones et al.

Summary: In a study of SARS-CoV-2 cases in Germany, it was found that younger subjects had lower viral loads but higher cell culture replication probabilities compared to older subjects. Additionally, 8% of subjects had viral loads above 10(9) copies per swab, with a third of them being presymptomatic, asymptomatic, or mildly symptomatic individuals with a mean age of 37.6 years. The B.1.1.7 lineage infections had a higher viral load and cell culture replication probability than non-B.1.1.7 subjects.

SCIENCE (2021)

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Article Public, Environmental & Occupational Health

Outbreak of SARS-CoV-2 Infections, Including COVID-19 Vaccine Breakthrough Infections, Associated with Large Public Gatherings — Barnstable County, Massachusetts, July 2021

Catherine M. Brown et al.

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT (2021)

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Review Infectious Diseases

SARS-CoV-2, SARS-CoV, and MERS-CoV viral load dynamics, duration of viral shedding, and infectiousness: a systematic review and meta-analysis

Muge Cevik et al.

Summary: This study aimed to characterize the viral load dynamics, duration of viral shedding, and viable virus shedding of SARS-CoV-2 in various body fluids. The findings suggest that while SARS-CoV-2 RNA shedding can be prolonged in respiratory and stool samples, the duration of viable virus shedding is relatively short-lived.

LANCET MICROBE (2021)

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Article Cell Biology

Modeling the impact on virus transmission of Wolbachia-mediated blocking of dengue virus infection of Aedes aegypti

Neil M. Ferguson et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

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Community transmission and viral load kinetics of the SARS-CoV-2 delta (B.1.617.2) variant in vaccinated and unvaccinated individuals in the UK: a prospective, longitudinal, cohort study

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