4.7 Article

Microfluidic-based in vitro thrombosis model for studying microplastics toxicity

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Veterinary Sciences

Fetal morphological features and abnormalities associated with equine early pregnancy loss

Anne Kahler et al.

Summary: This study compared the morphology of equine early pregnancy loss (EPL) to normal embryos/fetuses and found mismatches between size and age, alterations in neural tissue, and localized subcutaneous hemorrhage in EPL embryos/fetuses. Failed neural tube closure was identified as a rare specific abnormality.

EQUINE VETERINARY JOURNAL (2021)

Review Materials Science, Biomaterials

Pharmacokinetics-On-a-Chip: In Vitro Microphysiological Models for Emulating of Drugs ADME

Qasem Ramadan et al.

Summary: Despite the ongoing efforts in pharmaceutical and biotech industries, drug development remains costly and high-risk, with debates over the use of animal models due to ethical concerns and pathophysiological differences between animals and humans. Current in vitro models lack the functionality to fully replace animal models, but the development of micro-physiological systems shows potential as tools for predicting human pharmacokinetics and pharmacodynamics. The integration of ADME processes in vitro is a significant development meeting important pharmaceutical industry needs.

ADVANCED BIOLOGY (2021)

Article Environmental Sciences

Plasticenta: First evidence of microplastics in human placenta

Antonio Ragusa et al.

Summary: The study revealed the presence of microplastic fragments in human placentas, with different shapes and possible origins from man-made coatings, paints, adhesives, etc.

ENVIRONMENT INTERNATIONAL (2021)

Article Environmental Sciences

Cardiovascular toxicity assessment of polyethylene nanoplastics on developing zebrafish embryos

Mengqi Sun et al.

Summary: The study revealed that nanoplastics can induce cardiovascular toxicity in zebrafish embryos, causing issues such as severe pericardial edema, decreased cardiac output, and slowed blood flow velocity. Additionally, nanoplastics may lead to vascular endothelial dysfunction, hypercoagulable blood state, and systemic inflammation.

CHEMOSPHERE (2021)

Article Environmental Sciences

Environmental microplastic and nanoplastic: Exposure routes and effects on coagulation and the cardiovascular system

Zachary Lett et al.

Summary: Plastic pollution, particularly microplastics and nanoplastics, poses a significant threat to aquatic and terrestrial ecosystems. Research indicates that the size and surface chemistry of plastic particles play a crucial role in their interactions and effects on thrombosis and the cardiovascular system. Further studies are needed to fully understand the physiological impact of environmental plastic exposure and develop effective solutions to mitigate its effects.

ENVIRONMENTAL POLLUTION (2021)

Editorial Material Multidisciplinary Sciences

Microplastics and human health

A. Dick Vethaak et al.

SCIENCE (2021)

Review Environmental Sciences

Potential human health risks due to environmental exposure to nano-and microplastics and knowledge gaps: A scoping review

Arifur Rahman et al.

Summary: Microplastics are an emerging global environmental contaminant that may have negative impacts on human health through various pathways such as metabolic disturbances, neurotoxicity, and increased cancer risk. Currently, little is known about the effects of microplastics on human health, and further research is needed to quantify their impacts and pathogenesis.

SCIENCE OF THE TOTAL ENVIRONMENT (2021)

Article Chemistry, Multidisciplinary

An Oxygen-Concentration-Controllable Multiorgan Microfluidic Platform for Studying Hypoxia-Induced Lung Cancer-Liver Metastasis and Screening Drugs

Lulu Zheng et al.

Summary: A three-dimensional-culture multiorgan microfluidic platform was developed to study cancer metastasis mechanisms and drug screening. The research showed that hypoxia-induced lung cancer cells could promote metastasis through the HIF-1 alpha pathway, and inhibiting HIF-1 alpha effectively treated lung cancer under hypoxic conditions. The platform has the potential to replace animal experiments and become an important tool for future cancer research and drug screening.

ACS SENSORS (2021)

Article Nanoscience & Nanotechnology

Touchable cell biophysics property recognition platforms enable multifunctional blood smart health care

Longfei Chen et al.

Summary: The article proposes a smart optofluidic system for differential diagnosis in blood testing by recognizing cell biophysical properties mechanically and morphologically. By using a smartphone algorithm and artificial intelligence-based modeling, online testing is achieved with increased diagnostic accuracy for typical blood diseases, and personalized blood quality monitoring is also possible. This work suggests a potential basis for next-generation blood smart health care devices.

MICROSYSTEMS & NANOENGINEERING (2021)

Article Environmental Sciences

Impact and Molecular Mechanism of Microplastics on Zebrafish in the Presence and Absence of Copper Nanoparticles

Ning Gao et al.

Summary: This study evaluated the toxic effects of polystyrene microplastics with different particle sizes on zebrafish and found that the toxicity sequence of microplastics was 7 μm > 0.07 μm > 0.7 μm. It was observed that microplastics affected zebrafish chromosomes and cell cycle processes, with different-sized microplastics acting on different cellular components and pathways.

FRONTIERS IN MARINE SCIENCE (2021)

Article Multidisciplinary Sciences

A microfluidic chip enables fast analysis of water microplastics by optical spectroscopy

Ahmed A. Elsayed et al.

Summary: A micro-optofluidic platform is proposed for fast quantification of microplastic particles in drinking water, utilizing micro-reservoirs and filters for quick imaging and spectroscopy. Passive size sorting and flow cytometry are used to further analyze and differentiate the particles based on size and chemical nature. Validation using model samples demonstrates the feasibility of this platform for microplastic detection.

SCIENTIFIC REPORTS (2021)

Article Biochemical Research Methods

Investigations on T cell transmigration in a human skin-on-chip (SoC) model

Xiaoou Ren et al.

Summary: A three-dimensional skin-on-chip model was developed to study the migration of human T lymphocytes in inflammatory microenvironments. Results showed that T cell migration can be inhibited by engineered CCL20 locked dimer and S1P background, while inflammatory cytokine stimulated epithelial cells can induce T cell transmigration in the model.

LAB ON A CHIP (2021)

Article Biochemical Research Methods

Rapid nitrate determination with a portable lab-on-chip device based on double microstructured assisted reactors

Fang Wang et al.

Summary: A portable device utilizing innovative three-dimensional double microstructured assisted reactors was developed for rapid nitrate determination. The device showed fast detection speed, low reagent consumption, good reproducibility, and low toxic reagent consumption, indicating a wide range of applications in water quality monitoring.

LAB ON A CHIP (2021)

Article Biochemical Research Methods

A flux-adaptable pump-free microfluidics-based self-contained platform for multiplex cancer biomarker detection

Bo Dai et al.

Summary: Microfluidics plays a crucial role in advancing portable and cost-effective bioanalytical diagnostics. A pump-free microfluidic chip has been developed for rapid and sensitive detection of multiple biomarkers, offering potential applications in disease monitoring.

LAB ON A CHIP (2021)

Review Public, Environmental & Occupational Health

The impact of ambient temperature on the incidence of urolithiasis: a systematic review and meta-analysis

Yucong Zhang et al.

SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH (2020)

Article Engineering, Environmental

Polystyrene microplastic particles: In vitro pulmonary toxicity assessment

Cheng-Di Dong et al.

JOURNAL OF HAZARDOUS MATERIALS (2020)

Review Environmental Sciences

Environmental exposure to microplastics: An overview on possible human health effects

Joana Correia Prata et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2020)

Article Chemistry, Multidisciplinary

A Portable and Accurate Phosphate Sensor Using a Gradient Fabry- Perot Array

Jiaomeng Zhu et al.

ACS SENSORS (2020)

Article Chemistry, Multidisciplinary

Optical Potential-Well Array for High-Selectivity, Massive Trapping and Sorting at Nanoscale

Yuzhi Shi et al.

NANO LETTERS (2020)

Review Toxicology

The plastic brain: neurotoxicity of micro- and nanoplastics

Minne Prust et al.

PARTICLE AND FIBRE TOXICOLOGY (2020)

Article Biotechnology & Applied Microbiology

Plasma proteins facilitates placental transfer of polystyrene particles

Michael M. Gruber et al.

JOURNAL OF NANOBIOTECHNOLOGY (2020)

Article Multidisciplinary Sciences

Environmental exposure enhances the internalization of microplastic particles into cells

A. F. R. M. Ramsperger et al.

SCIENCE ADVANCES (2020)

Article Biochemical Research Methods

Versatile biomimetic array assembly by phase modulation of coherent acoustic waves

Xuejia Hu et al.

LAB ON A CHIP (2020)

Review Chemistry, Multidisciplinary

Microfluidic immobilized enzyme reactors for continuous biocatalysis

Yujiao Zhu et al.

REACTION CHEMISTRY & ENGINEERING (2020)

Article Environmental Sciences

An assessment of the toxicity of polypropylene microplastics in human derived cells

Jangsun Hwang et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2019)

Article Medicine, General & Internal

Detection of Various Microplastics in Human Stool A Prospective Case Series

Philipp Schwabl et al.

ANNALS OF INTERNAL MEDICINE (2019)

Article Multidisciplinary Sciences

Continuous artificial synthesis of glucose precursor using enzyme-immobilized microfluidic reactors

Yujiao Zhu et al.

NATURE COMMUNICATIONS (2019)

Article Environmental Sciences

Microplastics detected in haemolymph of the Sydney rock oyster Saccostrea glomerata

Elliot Scanes et al.

MARINE POLLUTION BULLETIN (2019)

Article Environmental Sciences

Polystyrene microplastics induce microbiota dysbiosis and inflammation in the gut of adult zebrafish

Yuanxiang Jin et al.

ENVIRONMENTAL POLLUTION (2018)

Article Environmental Sciences

Polystyrene microplastics induce gut microbiota dysbiosis and hepatic lipid metabolism disorder in mice

Liang Lu et al.

SCIENCE OF THE TOTAL ENVIRONMENT (2018)

Article Multidisciplinary Sciences

A microengineered vascularized bleeding model that integrates the principal components of hemostasis

Yumiko Sakurai et al.

NATURE COMMUNICATIONS (2018)

Review Engineering, Environmental

Plastic and Human Health: A Micro Issue?

Stephanie L. Wright et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)

Article Biochemical Research Methods

Skeletal muscle-on-a-chip: an in vitro model to evaluate tissue formation and injury

Gaurav Agrawal et al.

LAB ON A CHIP (2017)

Article Engineering, Biomedical

Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium

Abhishek Jain et al.

BIOMEDICAL MICRODEVICES (2016)