期刊
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
卷 30, 期 2, 页码 419-427出版社
SPRINGER
DOI: 10.1007/s00167-021-06811-5
关键词
Total knee arthroplasty; Coronal alignment; Kinematic alignment; Phenotype alignment; Personalised medicine; Safe zone
资金
- Department of Orthopaedic Surgery and Traumatology of the Cantonal Hospital Baselland
- research group DKF Knee of the University of Basel
The aim of this systematic review is to investigate whether alignment outside the safe zone of +/- 3 degrees in total knee arthroplasty (TKA) is associated with a higher revision rate and worse clinical outcome than alignment within this range. The results showed no significant differences in clinical outcomes and revision rates between implants positioned within +/- 3 degrees and those outside this range. However, further research is needed to determine the optimal alignment strategies and thresholds for different patient-specific alignment strategies.
Purpose In total knee arthroplasty (TKA), implants are increasingly aligned based on emerging patient-specific alignment strategies, such as unrestricted kinematic alignment (KA), according to their constitutional limb alignment (phenotype alignment), which results in a large proportion of patients having a hip-knee angle (HKA) outside the safe range of +/- 3 degrees to 180 degrees traditionally considered in the mechanical alignment strategy. The aim of this systematic review is to investigate whether alignment outside the safe zone of +/- 3 degrees is associated with a higher revision rate and worse clinical outcome than alignment within this range. Methods A systematic literature search was conducted in PubMed, Embase, Cochrane and World of Science, with search terms including synonyms and plurals for total knee arthroplasty, alignment, outlier, malalignment, implant survival and outcome. Five studies were identified with a total number of 927 patients and 952 implants. The Oxford Knee Score (OKS) and the WOMAC were used to evaluate the clinical outcome. The follow-up period was between 6 months and 10 years. Results According to HKA 533 knees were aligned within +/- 3 degrees, 47 (8.8%) were varus outliers and 121 (22.7%) were valgus outliers. No significant differences in clinical outcomes were found between implants positioned within +/- 3 degrees and varus and valgus outliers. Likewise, no significant differences were found regarding revision rates and implant survival. Conclusion The universal use of the safe zone of +/- 3 degrees derived from the mechanical alignment strategy is hardly applicable to modern personalised alignment strategies in the light of current literature. However, given the conflicting evidence in the literature on the risks of higher revision rates and poorer clinical outcomes especially with greater tibial component deviation, the lack of data on the outcomes of more extreme alignments, and regarding the use of implants for KA TKA that are actually designed for mechanical alignment, there is an urgent need for research to define eventual evidence-based thresholds for new patient-specific alignment strategies, not only for HKA but also for FMA and TMA, also taking into account the preoperative phenotype and implant design. It is of utmost clinical relevance for the application of modern alignment strategies to know which native phenotypes may be reproduced with a TKA.
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