4.4 Article

Impact of Post-Transplantation Hypomagnesemia on Long-Term Graft and Patient Survival after Transplantation

期刊

KIDNEY & BLOOD PRESSURE RESEARCH
卷 47, 期 5, 页码 341-353

出版社

KARGER
DOI: 10.1159/000522233

关键词

Hypomagenesemia; Calcineurin inhibitors; Renal allograft survival; Mortality

向作者/读者索取更多资源

Posttransplant hypomagnesemia is significantly associated with long-term patient and allograft outcomes in kidney transplant recipients, even after accounting for other factors.
Background: Post-transplant hypomagnesemia is commonly observed among patients prescribed calcineurin inhibitor (CNIs). Methods: We conducted a retrospective single-center analysis (2000-2013, N = 726) to examine the association of hypomagnesemia with long-term patient and allograft outcomes in kidney transplant recipients. A median serum magnesium (Mg) level of all measured Mg levels from 1 month to 1 year posttransplant was calculated. Results: For every increase in Mg of 0.1 mg/dL, the risk for either graft loss or death, overall mortality, and death with a functioning graft increased by 11%, 14%, and 12%, respectively (p < 0.01). In a multivariate model, patients with median Mg level >= 1.7 mg/dL had a reduced overall survival rate (HR 1.57, 95% CI: 1.04-2.38, p = 0.033) compared to those with median Mg level <1.7 mg/dL. This association was observed in subgroups of patients above 60 years old, in those who had a slow graft function (SGF) and in females. Conclusions: Posttransplant hypomagnesemia is associated with better patient and allograft survival up to 10 years posttransplant. This relationship remained significant after accounting for baseline allograft function, presence of SGF and CNI trough levels.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.4
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据