4.7 Article

Nonparametric Parameters of 24-Hour Rest-Activity Rhythms and Long-Term Cognitive Decline and Incident Cognitive Impairment in Older Men

出版社

OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glab275

关键词

Circadian rhythms; Cognitive impairment; Dementia; Older adults; Rest and activity

资金

  1. National Institute of Aging [R01AG063946]
  2. National Institute on Aging (NIA)
  3. National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
  4. National Center for Advancing Translational Sciences (NCATS)
  5. NIH Roadmap for Medical Research [U01 AG027810, U01 AG042124, U01 AG042139, U01 AG042140, U01 AG042143, U01 AG042145, U01 AG042168, U01 AR066160, UL1 TR000128]
  6. National Heart, Lung, and Blood Institute (NHLBI) [R01 HL071194, R01 HL070848, R01 HL070847, R01 HL070842, R01 HL070841, R01 HL070837, R01 HL070838, R01 HL070839]

向作者/读者索取更多资源

Less stable and more variable rest-activity rhythms may serve as early biomarkers of cognitive impairment in older adults.
Altered 24-hour rest-activity rhythms may be associated with cognitive impairment in older adults, but evidence from prospective studies is limited. Nonparametric methods were used to assess actigraphy-based activity patterns in 2 496 older men. Incident cognitive impairment was assessed 4 times over 12 years using the Modified Mini-Mental State Examination (3MS) and Trails B tests, self-reported medication use, and clinical diagnosis. The highest quartile (vs the lowest) of intradaily variability and the lowest quartiles (vs the highest) of interdaily stability and relative amplitude were associated with incident cognitive impairment (hazard ratio [95% confidence interval]: 1.82 [1.31-2.53], 1.36 [0.99-1.86], and 1.85 [1.33-2.56], respectively). A larger increase in intradaily variability over 7.5 years was associated with a greater subsequent decline in 3MS scores but not in Trails B performance. In conclusion, less stable and more variable rest-activity rhythms may represent early biomarkers of cognitive impairment in older men.

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