期刊
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
卷 77, 期 4, 页码 837-841出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/gerona/glab374
关键词
Death; Epidemiology; Family study; Fatigue
资金
- National Institutes of Health/National Institute on Aging [U01 AG023712, U01 AG023744, U01 AG023746, U01 AG023749, U01 AG023755, P01 AG08761, U19 AG063893, K01 AG057798]
- National Institutes of Health/National Institute on Aging, University of Pittsburgh Claude D. Pepper Older Americans Independence Center, Research Registry and Developmental Pilot Grant [P30 AG024827]
- National Institute on Aging
- National Institute on Aging, Epidemiology of Aging training grant at the University of Pittsburgh [T32 AG000181]
Perceived physical fatigability is a common issue among older adults and is associated with mobility decline and other health consequences. This study found that perceived physical fatigability is independently associated with the risk of death among older adults, with higher fatigability scores indicating a higher risk of death.
Background Perceived physical fatigability is highly prevalent in older adults and associated with mobility decline and other health consequences. We examined the prognostic value of perceived physical fatigability as an independent predictor of risk of death among older adults. Methods Participants (N = 2 906), mean age 73.5 [SD, 10.4] years, 54.2% women, 99.7% white enrolled in the Long Life Family Study, were assessed at Visit 2 (2014-2017) with 2.7 [SD, 1.0] years follow-up. The Pittsburgh Fatigability Scale (PFS), a 10-item, self-administered validated questionnaire (score range 0-50, higher = greater fatigability) measured perceived physical fatigability at Visit 2. Deaths post-Visit 2 through December 31, 2019 were identified by family members notifying field centers, reporting during another family member's annual phone follow-up, an obituary, or Civil Registration System (Denmark). We censored all other participants at their last contact. Cox proportional hazard models predicted mortality by fatigability severity, adjusted for family relatedness and other covariates. Results Age-adjusted PFS Physical scores were higher for those who died (19.1 [SE, 0.8]) compared with alive (12.2, [SE, 0.4]) overall, as well as across age strata (p < .001), except for those 60-69 years (p = .79). Participants with the most severe fatigability (PFS Physical scores >= 25) were over twice as likely to die (hazard ratio, 2.33 [95% CI, 1.65-3.28]) compared with those who had less severe fatigability (PFS Physical scores < 25) after adjustment. Conclusions Our work underscores the utility of the PFS as a novel patient-reported prognostic indicator of phenotypic aging that captures both overt and underlying disease burden that predicts death.
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