Characterization of DNA methylation as well as mico-RNA expression and screening of epigenetic markers in adipogenesis

Article Biochemistry & Molecular Biology

Construction of Adipogenic ceRNA Network Based on lncRNA Expression Profile of Adipogenic Differentiation of Human MSC Cells

Chengcheng Liang et al.

Summary: The study analyzed and predicted the lncRNA expression data during MSC adipogenic differentiation, revealing important molecular mechanisms and pathways related to obesity in the ceRNA network.

BIOCHEMICAL GENETICS (2022)

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Article Cell Biology

Overexpression of TICRR and PPIF confer poor prognosis in endometrial cancer identified by gene co-expression network analysis

Linlin Yang et al.

Aging-US (2021)

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Article Biochemistry & Molecular Biology

Type III Collagen is Required for Adipogenesis and Actin Stress Fibre Formation in 3T3-L1 Preadipocytes

Mohammad Al Hasan et al.

Summary: The research demonstrated the essential role of ColIII in adipogenesis of 3T3-L1 preadipocytes and the formation of actin stress fibers. Knocking out the Col3a1 gene significantly decreased adipogenesis and cell adhesion, leading to deregulation of collagen and other extracellular matrix gene transcripts.

BIOMOLECULES (2021)

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Article Cell Biology

A Wnt5a-Cdc42 axis controls aging and rejuvenation of hair-follicle stem cells

Rajiv L. Tiwari et al.

Summary: As aging progresses, hair regeneration is impaired due to changes in the signaling pathways of HFSCs, such as a shift from canonical to non-canonical Wnt signaling. However, treatment with a specific pharmacological inhibitor can restore the functional deficits in aged HFSCs.

AGING-US (2021)

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Review Pharmacology & Pharmacy

The pivotal role of Nrf2 activators in adipocyte biology

A. S. Annie-Mathew et al.

Summary: Adipose tissue plays a crucial role in maintaining metabolic homeostasis, but overnutrition can lead to abnormal increase in adipocytes, causing obesity and other chronic complications. Oxidative stress is closely involved in the pathogenesis of obesity, and the Nrf2 signaling pathway plays a significant role in regulating oxidative and inflammatory responses. Researchers are currently seeking novel compounds to modulate Nrf2 activity for the management of adipogenesis and obesity.

PHARMACOLOGICAL RESEARCH (2021)

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Article Cell Biology

Epigenetic modifications underlie the differential adipogenic potential of preadipocytes derived from human subcutaneous fat tissue

Yoshitaka Kubota et al.

Summary: Ceiling culture-derived preadipocytes (ccdPAs) and adipose-derived stem cells (ASCs) were isolated from human subcutaneous fat tissue and showed differences in adipogenic potential due to variations in methylation and histone modification levels of adipogenesis-related genes, such as PPARc, fatty acid-binding protein 4, and leptin. Genomewide epigenetic analysis revealed distinct patterns in CpG methylation and H3K4me3 modification between ccdPAs and ASCs, suggesting epigenetic mechanisms underlying adipogenic differentiation capabilities of these cell types.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2021)

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Article Biochemistry & Molecular Biology

miR-148a-3p silences the CANX/MHC-I pathway and impairs CD8(+) T cell-mediated immune attack in colorectal cancer

Jinxiu Zheng et al.

Summary: Low expression of MHC-I on tumor cells is a key mechanism of tumor escape from T-cell recognition. High levels of CANX in tumors are associated with better overall survival in colorectal cancer patients. Inhibition of miR-148a-3p can restore MHC-I surface levels and enhance immune attack by promoting CANX expression.

FASEB JOURNAL (2021)

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Review Cell Biology

Insulin/IGF-1 signaling promotes immunosuppression via the STAT3 pathway: impact on the aging process and age-related diseases

Antero Salminen et al.

Summary: The insulin/IGF-1 signaling pathway and STAT3 signaling pathway are closely related, playing important roles in immunosuppressive cells, inflammation, and cellular senescence. Excessive activation may promote the aging process by inducing insulin resistance and cellular senescence.

INFLAMMATION RESEARCH (2021)

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Review Biochemistry & Molecular Biology

The PPARβ/δ-AMPK Connection in the Treatment of Insulin Resistance

David Aguilar-Recarte et al.

Summary: Activators of PPAR beta/delta show promise in preventing and treating type 2 diabetes mellitus, mainly through AMPK activation. Further understanding of the mechanisms underlying the effects of the PPAR beta/delta-AMPK pathway may provide a basis for the development of new therapies.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Insulin Signal Transduction Perturbations in Insulin Resistance

Mariyam Khalid et al.

Summary: Type 2 diabetes mellitus is characterized by high blood glucose and inadequate insulin action, caused by insulin resistance which involves multiple molecular and pathophysiological mechanisms. Although various factors like metabolic disorders, lipotoxicity, and inflammation contribute to insulin resistance, a central underlying mechanism has yet to be identified. This review focuses on defects in insulin signal transduction pathway, emphasizing the importance of the AGE-RAGE-NF-kappa B axis, in providing new insights for future interventions in type 2 diabetes mellitus.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Biochemistry & Molecular Biology

Roles of MicroRNAs in Osteogenesis or Adipogenesis Differentiation of Bone Marrow Stromal Progenitor Cells

Ya-Li Zhang et al.

Summary: The differentiation switch of BMSCs can lead to changes in bone/fat formation in the bone marrow, causing bone growth defects and disordered bone metabolism. MicroRNAs may play a significant role in regulating this process.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Article Medicine, Research & Experimental

Oleuropein reduces cisplatin resistance in ovarian cancer by targeting apoptotic pathway regulators

Somayeh Hashemi Sheikhshabani et al.

Summary: The study revealed that oleuropein regulated the expression of miRNAs in ovarian cancer cells, potentially resulting in apoptosis induction, cell proliferation inhibition, and decline in cisplatin resistance. Further experiments in animal models of ovarian cancer are suggested to confirm the findings.

LIFE SCIENCES (2021)

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Article Cell Biology

Targeting the Lnc-OPHN1-5/androgen receptor/hnRNPA1 complex increases Enzalutamide sensitivity to better suppress prostate cancer progression

Meng Zhang et al.

Summary: The study identified that lnc-OPHN1-5 plays a role in increasing prostate cancer sensitivity to Enzalutamide by regulating AR protein expression. The mechanism involves lnc-OPHN1-5 interacting with AR-mRNA to influence ribosome association and translation by modulating hnRNPA1.

CELL DEATH & DISEASE (2021)

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Article Cell Biology

MCL-1 Inhibition Overcomes Anti-apoptotic Adaptation to Targeted Therapies in B-Cell Precursor Acute Lymphoblastic Leukemia

Albert Manzano-Munoz et al.

Summary: Multiple targeted therapies are being explored for improving clinical outcome in pediatric and young adult BCP-ALL, especially for relapsed patients. Using DBP evaluation, MEK inhibitor trametinib and multi-target tyrosine kinase inhibitor sunitinib were found to enhance apoptotic priming in NRAS-mutant and KMT2A-rearranged cell lines with high FLT3 expression, respectively.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Cardiac & Cardiovascular Systems

The blooming intersection of subfatin and metabolic syndrome

Shenglei Huang et al.

Summary: Subfatin, a novel secreted protein in adipose tissue, plays a significant role in browning of white adipose tissue and insulin resistance, and is considered as a potential new target for the treatment of coronary heart disease. It improves glucose tolerance, increases heat production of brown fat, promotes energy consumption, and enhances anti-inflammatory mechanisms. Its clinical significance and role as a biomarker of metabolic syndrome remain unclear, warranting further research.

REVIEWS IN CARDIOVASCULAR MEDICINE (2021)

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Article Cell Biology