4.6 Article

Dietary alpha-linolenic acid reduces platelet activation and collagen-mediated cell adhesion in sickle cell disease mice

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Hematology

DHA 12-LOX-derived oxylipins regulate platelet activation and thrombus formation through a PKA-dependent signaling pathway

Adriana Yamaguchi et al.

Summary: DHA and its 12-LOX oxylipins, 11-HDHA and 14-HDHA, attenuate platelet aggregation, inhibit IIb β3 activation, decrease α-granule secretion, impair platelet adhesion and accumulation, and inhibit thrombus formation. The protective mechanism of DHA oxylipins is mediated via activation of protein kinase A, supporting their use as therapeutic intervention in atherothrombotic diseases.

JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2021)

Article Cardiac & Cardiovascular Systems

Long-term dietary supplementation with plant-derived omega-3 fatty acid improves outcome in experimental ischemic stroke

Nicole R. Bonetti et al.

Summary: A long-term dietary intervention with ALA has been shown to reduce stroke size and neurological dysfunction, maintain BBB integrity, and decrease inflammation. These findings suggest that ALA supplementation could pave the way for novel stroke treatments.

ATHEROSCLEROSIS (2021)

Article Multidisciplinary Sciences

Lifelong dietary omega-3 fatty acid suppresses thrombotic potential through gut microbiota alteration in aged mice

Seyed Soheil Saeedi Saravi et al.

Summary: This study demonstrates that lifelong intake of ALA can reduce platelet hyperresponsiveness and thrombus formation in aged mice, partly attributed to alteration of microbial composition, reduction of trimethylamine-N-oxide, and changes in inflammatory mediators.

ISCIENCE (2021)

Article Pharmacology & Pharmacy

Crizanlizumab: First Approval

Hannah A. Blair

Review Hematology

Effective use of hydroxyurea for sickle cell anemia in low-resource countries

Alexandra Power-Hays et al.

CURRENT OPINION IN HEMATOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Effects of Icosapent Ethyl on Total Ischemic Events From REDUCE-IT

Deepak L. Bhatt et al.

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY (2019)

Article Medicine, General & Internal

Marine n-3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer

JoAnn E. Manson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Crizanlizumab for the Prevention of Pain Crises in Sickle Cell Disease

K. I. Ataga et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Review Medicine, General & Internal

Sickle Cell Disease

Frederic B. Piel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Medicine, Research & Experimental

Lung vaso-occlusion in sickle cell disease mediated by arteriolar neutrophil-platelet microemboli

Margaret F. Bennewitz et al.

JCI INSIGHT (2017)

Article Medicine, General & Internal

Association of Seafood Consumption, Brain Mercury Level, and APOE ε4 Status With Brain Neuropathology in Older Adults

Martha Clare Morris et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2016)

Article Pediatrics

Sickle cell disease: a neglected chronic disease of increasing global health importance

Subarna Chakravorty et al.

ARCHIVES OF DISEASE IN CHILDHOOD (2015)

Article Cell Biology

Platelet Activation and Inhibition iN Sickle cell disease (PAINS) study

Andrew L. Frelinger et al.

PLATELETS (2014)

Article Peripheral Vascular Disease

Alpha-linolenic acid intake prevents endothelial dysfunction in high-fat diet-fed streptozotocin rats and underlying mechanisms

Wei Zhang et al.

VASA-EUROPEAN JOURNAL OF VASCULAR MEDICINE (2013)

Review Biochemistry & Molecular Biology

Fish oil and vascular endothelial protection: Bench to bedside

Pitchai Balakumar et al.

FREE RADICAL BIOLOGY AND MEDICINE (2012)

Review Biochemistry & Molecular Biology

n-3 Polyunsaturated fatty acids exert immunomodulatory effects on lymphocytes by targeting plasma membrane molecular organization

Saame Raza Shaikh et al.

MOLECULAR ASPECTS OF MEDICINE (2012)

Article Biochemical Research Methods

Fiji: an open-source platform for biological-image analysis

Johannes Schindelin et al.

NATURE METHODS (2012)

Article Hematology

Dietary α-Linolenic Acid Inhibits Arterial Thrombus Formation, Tissue Factor Expression, and Platelet Activation

Erik W. Holy et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)

Article Cardiac & Cardiovascular Systems

Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation

Stephan Winnik et al.

EUROPEAN HEART JOURNAL (2011)

Article Biochemistry & Molecular Biology

Omega-3 fatty acids modulate collagen signaling in human platelets

M. K. Larson et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2011)

Article Hematology

P-Selectin-Mediated Platelet-Neutrophil Aggregate Formation Activates Neutrophils in Mouse and Human Sickle Cell Disease

Renata Polanowska-Grabowska et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2010)

Article Medicine, General & Internal

Sickle-cell disease

David C. Rees et al.

LANCET (2010)

Article Biochemistry & Molecular Biology

Surprising up-regulation of P-selectin glycoprotein ligand-1 (PSGL-1) in endotoxin-induced uveitis

Lama Almulki et al.

FASEB JOURNAL (2009)

Article Public, Environmental & Occupational Health

Global epidemiology of haemoglobin disorders and derived service indicators

Bernadette Modell et al.

BULLETIN OF THE WORLD HEALTH ORGANIZATION (2008)

Review Medicine, General & Internal

Fish intake, contaminants, and human health - Evaluating the risks and the benefits

Dariush Mozaffarian et al.

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION (2006)

Article Biochemistry & Molecular Biology

Steady-state haemoglobin level in sickle cell anaemia increases with an increase in erythrocyte membrane n-3 fatty acids

HM Ren et al.

PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS (2005)

Review Biochemistry & Molecular Biology

Docosahexaenoic acid: membrane properties of a unique fatty acid

W Stillwell et al.

CHEMISTRY AND PHYSICS OF LIPIDS (2003)

Article Medicine, General & Internal

Mercury, fish oils, and the risk of myocardial infarction

E Guallar et al.

NEW ENGLAND JOURNAL OF MEDICINE (2002)

Article Multidisciplinary Sciences

Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease

M Aslan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)