Mutational Landscape in Myeloproliferative Neoplasms: Implications on Prognosis and Clinical Management

Mutations are a critical piece in understanding how myeloproliferative neoplasms (MPNs) occur, specifically the pathobiology of JAK/STAT activation. Mutations play such an important role, in fact, that they are a key part of the diagnostic classification for these diseases. Furthermore, the mutational landscape of MPNs affects both the prognosis and the biology of disease progression. Current research in the field is focused on understanding how and why these mutations occur, as well as how to attack them to address disease at the time of progression or even before disease progression has occurred. J Natl Compr Canc Netw 2021;19(11.5):1362-1364 doi: 10.6004/jnccn.2021.5102

Automated summary

Mutations play a critical role in understanding the pathobiology of JAK/STAT activation in myeloproliferative neoplasms (MPNs), shaping the diagnostic classification, prognosis, and disease progression biology. Current research is focused on understanding the mechanisms of mutation occurrence and developing strategies to target them for disease management.