期刊
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
卷 126, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.jmbbm.2021.104996
关键词
Atherosclerosis; Bayesian; Carotid; Finite element; Inflation; Material constant; Plaque rupture; Yeoh
资金
- European Commission [749283]
- Marie Curie Actions (MSCA) [749283] Funding Source: Marie Curie Actions (MSCA)
This study successfully predicted the component-wise material properties of atherosclerotic human carotid arteries ex-vivo using an inverse finite element modeling framework, demonstrating potential for pre-clinical applications.
Objective: Plaque rupture in atherosclerotic carotid arteries is a main cause of ischemic stroke and it is correlated with high plaque stresses. Hence, analyzing stress patterns is essential for plaque specific rupture risk assessment. However, the critical information of the multicomponent material properties of atherosclerotic carotid arteries is still lacking greatly. This work aims to characterize component-wise material properties of atherosclerotic human carotid arteries under (almost) physiological loading conditions. Methods: An inverse finite element modeling (iFEM) framework was developed to characterize fibrous intima and vessel wall material properties of 13 cross sections from five carotids. The novel pipeline comprised ex-vivo inflation testing, pre-clinical high frequency ultrasound for deriving plaque deformations, pre-clinical highmagnetic field magnetic resonance imaging, finite element modeling, and a sample efficient machine learning based Bayesian Optimization. Results: The nonlinear Yeoh constants for the fibrous intima and wall layers were successfully obtained. The optimization scheme of the iFEM reached the global minimum with a mean error of 3.8% in 133 iterations on average. The uniqueness of the results were confirmed with the inverted Gaussian Process (GP) model trained during the iFEM protocol. Conclusion: The developed iFEM approach combined with the inverted GP model successfully predicted component-wise material properties of intact atherosclerotic human carotids ex-vivo under physiological-like loading conditions. Significance: We developed a novel iFEM framework for the nonlinear, component-wise material characterization of atherosclerotic arteries and utilized it to obtain human atherosclerotic carotid material properties. The developed iFEM framework has great potential to be advanced for patient-specific in-vivo application.
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