期刊
INDIAN JOURNAL OF HEMATOLOGY AND BLOOD TRANSFUSION
卷 32, 期 -, 页码 S117-S120出版社
SPRINGER INDIA
DOI: 10.1007/s12288-016-0679-6
关键词
Primary myelofibrosis; Obstructive uropathy; Renal calculi; Acute kidney injury
类别
Primary myelofibrosis ( PMF) is a rare hematological disorder associated with progressive cytopenia and extra-medullary hematopoiesis. Acute kidney injury in this disease has been reported from diverse etiologies such as renal and peri-renal extramedullary hematopoiesis and tumor lysis syndrome. We report a patient who presented with obstructive uropathy from uric acid stones who was incidentally diagnosed with PMF during workup for persistent thrombocytosis and leukocytosis. Marrow histopathology was unique in presenting features of early PMF despite clinical picture mimicking essential thrombocythemia. Despite a common background of hyperuricemia in myeloproliferative neoplasms, AKI resulting from urate nephrolithiasis has seldom been reported in PMF. Published data on this association and clinical management is reviewed briefly.
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