期刊
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
卷 33, 期 1, 页码 15-32出版社
AMER SOC NEPHROLOGY
DOI: 10.1681/ASN.2021081073
关键词
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资金
- National Health and Medical Research Council of Australia Senior Principal Research Fellow grant [GNT1136085]
- National Institute of Diabetes and Digestive and Kidney Diseases grant from the (Re)Building a Kidney consortium [UC2DK126024]
This article reviews the changes in our understanding of kidney development, disease, repair, and regeneration over the past fifteen years, and envisions the future of kidney regeneration and repair for the next fifteen years.
Fifteen years ago, this journal published a review outlining future options for regenerating the kidney. At that time, stem cell populations were being identified in multiple tissues, the concept of stem cell recruitment to a site of injury was of great interest, and the possibility of postnatal renal stem cells was growing in momentum. Since that time, we have seen the advent of human induced pluripotent stem cells, substantial advances in our capacity to both sequence and edit the genome, global and spatial transcriptional analysis down to the single-cell level, and a pandemic that has challenged our delivery of health care to all. This article will look back over this period of time to see how our view of kidney development, disease, repair, and regeneration has changed and envision a future for kidney regeneration and repair over the next 15 years.
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