期刊
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
卷 144, 期 5, 页码 2107-2113出版社
AMER CHEMICAL SOC
DOI: 10.1021/jacs.1c13569
关键词
-
资金
- JSPS KAKENHI [JP18H04256]
- AGC Inc.
- [JP19H02710]
This study reports the development of a novel N-fluorinated imide (NFC) as a synthetic handle for the one-step derivatization to amines, sulfonamides, and sulfamides. It also demonstrates the superior reactivity of NFC in copper-catalyzed imidation of benzene derivatives and imidocyanation of aliphatic alkenes, overcoming the limitations of NFSI-mediated reactions.
Catalytic imidation using NFSI as the nitrogen source has become an emerging tool for oxidative carbon-nitrogen bond formation. However, the less than ideal benzenesulfonimide moiety is incorporated into products, severely detracting its synthetic value. As a solution to this challenge, we report herein the development of a novel N-fluorinated imide, N-fluoro-N-(fluorosulfonyl)carbamate (NFC), by which the attached imide moiety acts as a modular synthetic handle for one-step derivatization to amines, sulfonamides, and sulfamides. Furthermore, this study revealed the superior reactivity of NFC as showcased in a copper-catalyzed imidation of benzene derivatives and imidocyanation of aliphatic alkenes, overcoming the limitation of NFSI-mediated reactions.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据