期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 125, 期 6, 页码 1013-1023出版社
WILEY
DOI: 10.1002/jso.26817
关键词
aerobic fitness; colorectal cancer surgery; complication development and subsequent recovery; muscle density; preoperative risk assessment
资金
- Medical Research Data Management (MRDM)
- Ministry of Economic Affairs [LSHM17073]
This study assessed the association between preoperative aerobic fitness and body composition variables with the development and impact of postoperative complications in colorectal cancer patients. The results showed that better preoperative aerobic fitness decreased the likelihood of developing complications, while low muscle density was associated with prolonged recovery from complications.
Background and Objectives To assess the association of preoperative aerobic fitness and body composition variables with a patient's resilience to the development and impact of postoperative complications after elective colorectal cancer (CRC) surgery. Methods Preoperative aerobic fitness was assessed by steep ramp test performance. Preoperative body composition was assessed by muscle mass and density determined from preoperative computed tomography scan analysis at the L3-level. Complication development and severity was graded according to Clavien-Dindo. Complication impact was assessed by the time to recovery of physical functioning after complications. Multivariable logistic regression analyses adjusted for age, sex, comorbidities and tumour location was performed. Results Of 238 included patients, 96 (40.3%) developed postoperative complications. Better preoperative aerobic fitness decreased the likelihood to develop complications, independent of muscle mass (odds ratio [OR]: 0.55, 95% confidence interval [CI]: 0.35-0.85) or muscle density (OR: 0.57, 95% CI: 0.36-0.89). A prolonged time to recovery following complications was associated with lower preoperative muscle density (OR: 4.14, 95% CI: 1.28-13.41), independent of aerobic fitness. Conclusions Lower aerobic fitness increases the risk of complication development, while low muscle density seems associated with a prolonged recovery from complications. Aerobic fitness and muscle density could be valuable additives to preoperative risk assessment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据