期刊
JOURNAL OF SURGICAL ONCOLOGY
卷 124, 期 6, 页码 962-966出版社
WILEY
DOI: 10.1002/jso.26696
关键词
HPV-associated; oropharynx cancer; treatment de-escalation
资金
- National Cancer Institute [P30CA008748]
HPV-related oropharynx squamous cell carcinomas are sensitive to radiotherapy and chemotherapy, with treatment de-intensification aiming to reduce toxicity while maintaining efficacy. While substituting cisplatin with cetuximab or omitting chemotherapy have not been successful, Transoral Robotic Surgery with de-intensified adjuvant therapy has shown promise. Personalized approaches utilizing tumor biology and predictive markers on imaging have successfully reduced the intensity of radiotherapy and chemotherapy.
HPV-associated oropharynx squamous cell carcinomas are radiosensitive and chemosensitive, thus, portending a favorable prognosis. Treatment de-intensification strategies aim to reduce toxicity while maintaining efficacy. Although approaches that have substituted cisplatin with cetuximab or omitted chemotherapy have not been successful, Transoral Robotic Surgery with de-intensified adjuvant therapy has been promising. Additionally, personalized approaches are taking advantage of tumor biology and utilizing tumor reduction or hypoxia on imaging as a predictive marker to successfully de-escalate radiotherapy and chemotherapy.
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