4.5 Article

Fully supercritical CO2 preparation of a nanostructured MOF composite with application in cutaneous drug delivery

期刊

JOURNAL OF SUPERCRITICAL FLUIDS
卷 178, 期 -, 页码 -

出版社

ELSEVIER
DOI: 10.1016/j.supflu.2021.105379

关键词

Supercritical CO2; Nanostructured MOF; Drug impregnation; Polymer patches; Drug release

资金

  1. Spanish Ministry of Science and Innovation MICINN through the Severo Ochoa Program for Centers of Excellence [CEX2019-000917-S]
  2. Spanish National Plan of Research [CTQ2017-83632, PID2020-115631GB-I00]
  3. Multi-functional Metallodrugs in Diagnosis and Therapy Network (MICIU) [RED2018-102471-T]
  4. European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie Cofund grant [MSCA-COFUND-DP/0320-754397]
  5. Spanish Ramon y Cajal Programme [2014-16823]
  6. Spanish Juan de la Cierva Incorporacion Fellowship [IJC2019-038894-I]
  7. regional Madrid founding (Talento 2017 Modality 2) [2017-T2/IND-5149]
  8. MOFSEIDON project (MCI/AEI/FEDER, UE) [PID2019-104228RB-I00]

向作者/读者索取更多资源

In this study, Supercritical CO2 technology was utilized as an efficient method to assist in the preparation of a cutaneous polymeric formulation containing metal-organic framework composites. Analysis using solid state techniques and in vitro/ex vivo tests on porcine skin showed that scCO2 impregnation is a simple and fast strategy for preparing composite devices capable of gradually releasing and diffusing drugs into the skin.
Supercritical CO2 (scCO(2)) technology is used here as an efficient method to assist in the preparation of a cutaneous polymeric formulation based on drug containing metal-organic framework composites. The supercritical fluid is used in three steps: (i) as a drying agent for the nanosized mesoporous matrix, (ii) as the impregnation vector of a topical antibiotic drug, and (iii) as a plasticizing and foaming fluid to obtain dispersions of the hybrid material into a biocompatible polymer, e.g., the macroporous patch. The materials were characterized using solid state techniques. The drug delivery and permeation profiles of the patches were investigated applying in vitro and ex vivo tests by using porcine skin. These analyses suggest that scCO(2) impregnation is an easy and fast strategy to prepare composite devices able to progressively release and diffuse the incorporated drug throughout the skin, paving the way to efficiently prepare cutaneous devices for topical or systemic therapies.

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