期刊
JOURNAL OF STRUCTURAL BIOLOGY
卷 213, 期 4, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jsb.2021.107805
关键词
Biomineralization; Amelogenesis; Evolution; Basement membrane; ACP4
资金
- NIDCR/NIH [R01DE027675, R56DE015846, UG3DE028849, R01DE028297, R01DE026769]
- Ministry of Science and Technology in Taiwan [108-2314-B-002-038-MY3]
- National Taiwan University Hospital [109-N4534]
- National Research Foundation of Korea (NRF) - Korea government [NRF2020R1A2C2100543]
This review focuses on the roles of 41 essential genes during the secretory stage of amelogenesis, proposing a molecular model for how enamel mineral ribbons attach and elongate, guiding future research on enamel formation.
The revolution in genetics has rapidly increased our knowledge of human and mouse genes that are critical for the formation of dental enamel and helps us understand how enamel evolved. In this graphical review we focus on the roles of 41 genes that are essential for the secretory stage of amelogenesis when characteristic enamel mineral ribbons initiate on dentin and elongate to expand the enamel layer to the future surface of the tooth. Based upon ultrastructural analyses of genetically modified mice, we propose a molecular model explaining how a cell attachment apparatus including collagen 17, alpha 6ss4 and alpha vss6 integrins, laminin 332, and secreted enamel proteins could attach to individual enamel mineral ribbons and mold their cross-sectional dimensions as they simultaneously elongate and orient them in the direction of the retrograde movement of the ameloblast membrane.
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