期刊
IMMUNOTHERAPY
卷 8, 期 4, 页码 425-434出版社
FUTURE MEDICINE LTD
DOI: 10.2217/imt-2015-0009
关键词
good manufacturing practice; leukemia; natural killer cells
类别
资金
- Associazione Italiana per la Ricerca sul Cancro (AIRC), Special Program Molecular Clinical Oncology, Milan, Italy
- Progetto Giovani Ricercatori, Policlinico di Modena
The antileukemic potential of natural killer (NK) cells has over the years raised considerable interest and new immune-based treatment protocols characterized by the infusion of freshly isolated or ex vivo activated and expanded effectors have been designed. Several aspects still need to be addressed, including the optimal timing of NK infusion during the course of the disease, the best preparative regimen, the origin of NK cells and the possible need of ex vivo NK cell manipulation before the infusion. The aims of this review are to discuss the experimental and clinical data available on the role played by NK cells for leukemia patients and to revise the different good manufacturing practice protocols for ex vivo manipulation of these effector cells.
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