Use of micro, capillary, and nano liquid chromatography for forensic analysis

The use of micro, capillary, and nano liquid chromatography systems for forensic analysis has excellent potential. In a field where sample size is often limited, several studies have presented the viability of capillary columns with microflow and nanoflow, and when using mass spectrometric analysis limits of detection can be improved. Reduction in flow rates result in significant reduction in operating costs. Recent advances in miniaturized liquid chromatography systems also aim at in-laboratory and on-site detection, which have already been applied to forensic drug cases. This critical review will discuss the advantages, disadvantages, and applicability of microflow and nano liquid chromatography. In this regard, included in this article is a discussion of some promising areas not yet applied to forensic research.

Automated summary

The use of micro, capillary, and nano liquid chromatography systems in forensic analysis shows great potential, especially in cases where sample size is limited. Reduction in flow rates can significantly lower operating costs and improve detection limits when using mass spectrometric analysis. Recent advances in miniaturized liquid chromatography systems also aim at in-laboratory and on-site detection, with promising areas not yet applied to forensic research being discussed.