期刊
JOURNAL OF SEPARATION SCIENCE
卷 45, 期 1, 页码 51-77出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jssc.202100593
关键词
chiral recognition material; chiral stationary phase; enantioseparation; high-performance liquid chromatography
资金
- NationalNatural Science Foundation of China [22064020, 91856123, 21765025, 21964021]
- AppliedBasic Research Foundation ofYunnan Province [2019FB011, 202101AT070101]
This article reviews the recent progress in the development of new chiral stationary phases for high-performance liquid chromatography, divided into three categories: small organic molecule-based, macromolecule-based, and chiral porous material-based. Each type of chiral stationary phase has unique characteristics and applications.
Separations and analyses of chiral compounds are important in many fields, including pharmaceutical production, preparation of chemical intermediates, and biochemistry. High-performance liquid chromatography using a chiral stationary phase is regarded as one of the most valuable methods for enantiomeric separation and analysis because it is highly efficient, is broadly applicable, and has powerful separation capability. The focus for development of this method is the identification of novel chiral stationary phases with superior recognition performance and good stability. The present article reviews recent progress in the development of new chiral stationary phases for high-performance liquid chromatography between January 2018 and June 2021. These newly reported chiral stationary phases are divided into three categories: small organic molecule-based (cyclodextrin and its derivatives, macrocyclic antibiotics, cinchona alkaloids, and other low molecular weight chiral molecules), macromolecule-based (cellulose and amylose derivatives, chitin and chitosan derivatives, and synthetic helical polymers) and chiral porous material-based (chiral metal-organic frameworks, chiral covalent organic frameworks, and chiral inorganic mesoporous silicas). Each type of chiral stationary phase is discussed in detail.
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