期刊
JOURNAL OF RHEUMATOLOGY
卷 49, 期 7, 页码 719-724出版社
J RHEUMATOL PUBL CO
DOI: 10.3899/jrheum.210755
关键词
epidemiology; juvenile idiopathic arthritis; juvenile psoriatic arthritis; psoriasis; uveitis
类别
资金
- Federal Ministry for Research and Education
- Deutsche Kinderrheuma-Stiftung
- AbbVie
- Chugai
- Pfizer
- GSK
- Novartis
Data on uveitis in juvenile psoriatic arthritis (JPsA) are scarce. Patients with JPsA-associated uveitis (JPsA-U) have similar characteristics to uveitis patients in other categories of juvenile idiopathic arthritis (JIA). Children with early-onset JPsA are at a higher risk for ocular involvement.
Objective. Data on uveitis in juvenile psoriatic arthritis (JPsA), a category of juvenile idiopathic arthritis (JIA), are scarce. We describe prevalence and risk factors for JPsA-associated uveitis (JPsA-U). Methods. Cross-sectional data from the German National Pediatric Rheumatological Database (2002-2014) were used to characterize JPsA-U and assess risk factors for the development of uveitis. Results. Uveitis developed in 6.6% of 1862 patients with JPsA. Patients with JPsA-U were more frequently female (73.0 vs 62.9%, P = 0.03), antinuclear antibody (ANA) positive (60.3 vs 37.0%, P < 0.001), younger at JPsA onset (5.3 +/- 4.1 vs 9.3 +/- 4.4 yrs, P < 0.001), and treated with disease-modifying antirheumatic drugs (DMARDs) significantly more frequently compared with JPsA patients without uveitis. On a multivari-able analysis of a subgroup of 655 patients enrolled in the study <= 1 year after arthritis onset, mean clinical Juvenile Arthritis Disease Activity Score for 10 joints during study documentation was significantly associ-ated with uveitis development. Children with early onset of JPsA (aged < 5 yrs vs >= 5 yrs) were significantly more frequently ANA positive (48.4% vs 35.7%, P < 0.001), affected by uveitis (17.3% vs 3.8%, P < 0.001), and treated with DMARDs (52.9% vs 43.8%, P < 0.001), but less often affected by skin disease (55.3% vs 61.0%, P = 0.03). Conclusion. The characteristics of patients with JPsA developing uveitis are similar to those of patients with uveitis in other JIA categories, such as oligoarticular JIA. Children with early-onset JPsA are at a higher risk for ocular involvement. Our data support the notion of a major clinical difference between those patients with early vs late onset of JPsA.
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