期刊
IMMUNOLOGY LETTERS
卷 169, 期 -, 页码 61-72出版社
ELSEVIER
DOI: 10.1016/j.imlet.2015.11.007
关键词
Cancer immunotherapy; Gamma chain cytokines; Hematopoietic malignancies; Solid cancers; Immunostimulation
类别
资金
- T32 grant [2T32H007735-17]
- [5 U54 RR026140-03]
- [8 U54 MD007593-04]
- [U54CA091408]
- [8 U54 MD007593-03]
- [R01CA175370]
- [5P50CA 090949]
- [SCI CA182843]
Common gamma chain (gamma C) cytokines, namely IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 are important for the proliferation, differentiation, and survival of lymphocytes that display antitumor activity, thus stimulating considerable interest for the use of cytokines in cancer immunotherapy. In this review, we will focus on the gamma C cytokines that demonstrate the greatest potential for immunotherapy, IL-2, IL-7, IL-15, and IL-21. We will briefly cover their biological function, potential applications in cancer therapy, and update on their use in combinatorial immune strategies for eradicating tumors and hematopoietic malignancies. (C) 2015 Elsevier B.V. All rights reserved.
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