Association of IL1R1 gene (SNP rs2071374) with the risk of preeclampsia

Background: Association of IL1R1rs2071374 with the risk of preeclampsia compared with normotensive pregnant women. Methodology: The study was a case-control study with 304 pregnant women comprising of preeclampsia (n = 152) and normotensive pregnancies (n = 152). And SNP rs2071374 was genotyped by PCR-RFLP method. Results: The presence of IL1R1rs2071374G allele was associated with the increased risk of preeclampsia P = 0.01741, odds ratio = 0.7006 (95% CI: 0.5023-0.9759). Conclusion: The results indicated that there was an association in IL1R1 rs2071374SNP with preeclampsia compared to non-preeclampsia women. It is the first study to evaluate that IL1R1 polymorphism is correlated with preeclampsia pathogenesis in the Population in India.

Automated summary

The study revealed an association between the IL1R1rs2071374G allele and increased risk of preeclampsia, suggesting that IL1R1 genetic polymorphism may impact the pathogenesis of preeclampsia in Indian population. This provides new insights into the genetic factors underlying the disease.