期刊
JOURNAL OF RADIATION RESEARCH
卷 62, 期 6, 页码 1114-1119出版社
OXFORD UNIV PRESS
DOI: 10.1093/jrr/rrab092
关键词
brain metastases; stereotactic radiosurgery (SRS); volumetric modulated arc therapy (VMAT); conformity index (CI)
资金
- JSPS KAKENHI [21 K15548]
- commissioned project of Varian Medical Systems
Comparing DCAT, CoVMAT, and NcVMAT plans in the treatment of single brain metastasis, it was found that NcVMAT significantly improved target conformity and reduced doses to normal brain tissue.
In the delivery of stereotactic radiosurgery (SRS) by linear accelerator (LINAC), dynamic conformal arc therapy (DCAT) with non-coplanar beams is conventionally used. However, volumetric modulated arc therapy (VMAT) can improve target conformity, thereby decreasing the dose to organs at risk by inversed planning methods, but few studies have directly compared DCAT and VMAT with and without non-coplanar beams in patients with single brain metastasis. We therefore conducted a planning study to compare the dose distribution in DCAT, VMAT using only a coplanar arc (CoVMAT) and VMAT with non-coplanar arcs (NcVMAT) in the treatment of single brain metastasis. DCAT, CoVMAT and NcVMAT plans were created for 15 patients. The three modalities were compared in terms of target conformity, target coverage, the dose to normal brain tissue, monitor units (MUs) and beam-on time. Both conformity indices (RTOG-CI and IP-CI) as well as the D-98% of the gross target volume (GTV) were significantly better in the NcVMAT plans than in the DCAT plans. Comparisons of the doses to normal brain tissue revealed that the V-20Gy, V-15Gy, V-12Gy, V-10Gy and V-5Gy were significantly smaller in the NcVMAT plans than in the plans based on the other two modalities. The MUs of the DCAT and NcVMAT plans were larger than those of the CoVMAT plans, and the beam-on time was longer in the NcVMAT and CoVMAT plans than in the DCAT plans. Compared to the CoVMAT and DCAT plans, NcVMAT plans significantly improved target conformity and reduced the doses to normal brain tissue at V-20Gy, V-15Gy, V-12Gy, V-10Gy and V-5Gy.
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