期刊
JOURNAL OF PSYCHIATRIC RESEARCH
卷 144, 期 -, 页码 304-311出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jpsychires.2021.10.028
关键词
Biomarkers; Bipolar disorder; Depression; Fatty acid-binding protein 7; Schizophrenia
类别
资金
- SENSHIN Medical Research Foundation
- Japan Society for the Promotion of Science(JSPS), KAKENHI [16K19189]
- Grants-in-Aid for Scientific Research [16K19189] Funding Source: KAKEN
The study found that plasma FABP7 concentrations were correlated with PANSS scores but not with other symptom assessment scales. In the analysis, the severity of depression/anxiety, cognition, and positive symptoms were significantly correlated with plasma FABP7 concentrations, indicating that FABP7 may be a biological indicator reflecting the pathogenesis of schizophrenia.
Because of the involvement of the brain in the pathophysiology of psychiatric disorders, obtaining information on the biochemical features that directly contribute to symptoms is challenging. The present study aimed to assess fatty acid-binding protein 7 (FABP7) expressed specifically in the brain and detectable in the peripheral blood and to investigate the correlation between blood FABP7 concentration and symptoms. We recruited 30, 29, and 35 patients with schizophrenia, bipolar disorder, and depression and evaluated using the Positive and Negative Syndrome Scale (PANSS), Young Mania Rating Scale (YMRS), and Hamilton Depression Rating Scale (HAMD-21), respectively. Plasma FABP7 concentrations correlated with PANSS scores (R-2 = 0.3305, p < 0.001) but not with other scales. In the analysis of the relationship between five dimensions of schizophrenia symptoms derived from the PANSS 5-factor model and measured plasma FABP7 concentrations, severities of depression/ anxiety, cognition, and positive symptom were significantly correlated with plasma FABP7 concentrations. Further molecular investigation of the functional and kinetic analyses of FABP7 is necessary to understand the relationship of this protein with schizophrenia pathology. Nevertheless, the present study suggests that FABP7 can be a biological indicator reflecting the pathogenesis of schizophrenia and has potential applications as a biomarker for diagnosis and symptom assessment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据