☆ 4.7 Article

Metabolic Snapshot of Plasma Samples Reveals New Pathways Implicated in SARS-CoV-2 Pathogenesis

JOURNAL OF PROTEOME RESEARCH (2022)

相关参考文献

注意：仅列出部分参考文献，下载原文获取全部文献信息。

Article Biochemical Research Methods

Nontargeted Serum Lipid Profiling of Nonalcoholic Steatohepatitis by Multisegment Injection-Nonaqueous Capillary Electrophoresis-Mass Spectrometry: A Multiplexed Separation Platform for Resolving Ionic Lipids

Ritchie Ly et al.

Summary: New methods are needed in global lipid profiling due to the complexity and diversity of lipids. This study introduces a robust data workflow using multisegment injection-nonaqueous capillary electrophoresis-mass spectrometry (MSI-NACE-MS) to select lipid features from serum extracts. The approach successfully annotated 270 serum lipid features, including 128 reliably measured ionic lipids, and differentiated high-risk and low-risk nonalcoholic steatohepatitis patients using a k-means clustering algorithm.

JOURNAL OF PROTEOME RESEARCH (2022)

添加到收藏夹

Review Biochemical Research Methods

CE-MS for metabolomics: Developments and applications in the period 2018-2020

Wei Zhang et al.

Summary: Capillary electrophoresis-mass spectrometry (CE-MS) has become a mature analytical technique in metabolomics, particularly for analyzing polar and charged metabolites efficiently. In recent years, there have been advancements in CE-MS methods and strategies for metabolomics, including improved interfacing techniques for coupling CE to MS, profiling metabolites in volume-restricted samples, and enhancing metabolic coverage.

ELECTROPHORESIS (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Large-Scale Multi-omic Analysis of COVID-19 Severity

Katherine A. Overmyer et al.

Summary: The study conducted RNA-seq and high-resolution mass spectrometry on blood samples from COVID-19-positive and COVID-19-negative patients, identifying molecular features associated with disease severity and outcomes, offering pathophysiological insights and therapeutic suggestions. The observed dysregulation of platelet function, blood coagulation, acute phase response, and endotheliopathy further illuminated the unique COVID-19 phenotype. The findings are presented through a web-based tool enabling interactive exploration and machine learning prediction of COVID-19 severity.

CELL SYSTEMS (2021)

添加到收藏夹

Article Chemistry, Analytical

Covid-19 Automated Diagnosis and Risk Assessment through Metabolomics and Machine Learning

Jeany Delafiori et al.

Summary: COVID-19 continues to pose a heavy burden worldwide, emphasizing the importance of patient screening and risk management. Our integration of machine learning algorithms with mass spectrometry led to the development of a rapid platform for distinguishing COVID-19 in plasma samples and providing tools for risk assessment, aiding in patient management and decision-making.

ANALYTICAL CHEMISTRY (2021)

添加到收藏夹

Review Infectious Diseases

Arginine depletion as a therapeutic approach for patients with COVID-19

Joseph M. Grimes et al.

Summary: Arginine depletion may be an effective therapeutic approach against COVID-19 by disrupting the host-virus relationship and inhibiting the virus life cycle in a low arginine environment. Several arginine-metabolizing enzymes in clinical development could be a viable option for treating COVID-19 and other viral diseases.

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2021)

添加到收藏夹

Article Biochemical Research Methods

Enhancing confidence of metabolite annotation in Capillary Electrophoresis-Mass Spectrometry untargeted metabolomics with relative migration time and in-source fragmentation

Maricruz Mamani-Huanca et al.

Summary: Capillary electrophoresis coupled to mass spectrometry is a powerful tool for untargeted metabolomics studies, although identification remains a challenge. This study developed a CE-MS search platform, validated its functionality with various biological samples, and determined the RMT tolerance percentage for metabolite searching.

JOURNAL OF CHROMATOGRAPHY A (2021)

添加到收藏夹

Article Virology

Understanding the pathophysiological changes via untargeted metabolomics in COVID-19 patients

Halef O. Dogan et al.

Summary: COVID-19 patients and healthy controls exhibit significant differences in metabolites such as purine, glutamine, leukotriene D4, and glutathione metabolism, suggesting their roles in the pathogenesis of the disease. Targeting these pathways with therapeutic approaches like selective leukotriene D4 receptor antagonists and glutamine supplementation may reduce the severity and mortality of COVID-19.

JOURNAL OF MEDICAL VIROLOGY (2021)

添加到收藏夹

Article Medicine, Research & Experimental

Metabolic reprogramming and epigenetic changes of vital organs in SARS-CoV-2-induced systemic toxicity

Shen Li et al.

Summary: The authors successfully reproduced the systemic toxicity and multiorgan involvement induced by SARS-CoV-2 in a mouse model through viral delivery, revealing that metabolic and epigenetic changes could contribute to the pathogenesis of COVID-19.

JCI INSIGHT (2021)

添加到收藏夹

Article Biochemistry & Molecular Biology

Comprehensive Meta-Analysis of COVID-19 Global Metabolomics Datasets

Zhiqiang Pang et al.

Summary: This study conducted a comprehensive meta-analysis of global metabolomics datasets from three countries to identify key metabolic signatures characterizing COVID-19 disease progression and clinical outcomes, providing important insights for clinical care and therapeutics development.

METABOLITES (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Patterns ofmyocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance

Tushar Kotecha et al.

Summary: Troponin elevation is common in hospitalized COVID-19 patients, and recovered patients can exhibit myocarditis-like injury and ischemic heart disease, with possible ongoing localized inflammation. However, there is no evidence of diffuse fibrosis or edema in the remote myocardium.

EUROPEAN HEART JOURNAL (2021)

添加到收藏夹

Review Nutrition & Dietetics

L-Arginine and COVID-19: An Update

Ayobami Adebayo et al.

Summary: L-Arginine may play a crucial role in COVID-19 by affecting endothelial cells and the immune system, and could potentially serve as a therapeutic tool based on recent clinical experimentations.

NUTRIENTS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Metabolomics analysis reveals a modified amino acid metabolism that correlates with altered oxygen homeostasis in COVID-19 patients

Jose C. Paez-Franco et al.

Summary: Using gas chromatography coupled to mass spectrometry, we identified significant changes in serum metabolites associated with severe and mild COVID-19 patients, particularly in altered amino acid catabolism. The study found that three alpha-hydroxyl acids of amino acid origin increased with disease severity, correlating with changes in oxygen saturation levels and clinical markers of lung damage. The conversion of alpha-keto acids to alpha-hydroxyl acids is suggested to play a role in maintaining NAD recycling in patients with altered oxygen levels during SARS-CoV-2 infection, highlighting the potential importance of amino acid supplementation.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Multidisciplinary Sciences

Targeted metabolomics identifies high performing diagnostic and prognostic biomarkers for COVID-19

Yamile Lopez-Hernandez et al.

Summary: Research using targeted metabolomics identified potential biomarkers for predicting the course of COVID-19, with panels including specific metabolites showing promising results in distinguishing different patient groups. If further studies confirm the diagnostic value of these plasma biomarkers, they could be used in clinical practice.

SCIENTIFIC REPORTS (2021)

添加到收藏夹

Article Medicine, General & Internal

Effects of adding L-arginine orally to standard therapy in patients with COVID-19: A randomized, double-blind, placebo-controlled, parallel-group trial. Results of the first interim analysis

Giuseppe Fiorentino et al.

Summary: In severe COVID-19 patients, oral L-arginine significantly reduces the length of hospitalization and decreases respiratory support at day 10 after starting the treatment.

ECLINICALMEDICINE (2021)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Patterns of myocardial injury in recovered troponin-positive COVID-19 patients assessed by cardiovascular magnetic resonance

Tushar Kotecha et al.

Summary: Troponin elevation is common in hospitalized COVID-19 patients, indicating potential myocardial injury. Using multi-parametric cardiovascular magnetic resonance, researchers found that recovered COVID-19 patients often exhibit myocarditis-like injury and ischemic damage. Interestingly, some patients showed signs of localized inflammation, while others had ischemic heart disease without prior history.

EUROPEAN HEART JOURNAL (2021)

添加到收藏夹

Article Chemistry, Analytical

Unveiling the Fragmentation Mechanisms of Modified Amino Acids as the Key for Their Targeted Identification

Maricruz Mamani-Huanca et al.

ANALYTICAL CHEMISTRY (2020)

添加到收藏夹

Article Biochemistry & Molecular Biology

Proteomic and Metabolomic Characterization of COVID-19 Patient Sera

Bo Shen et al.

CELL (2020)

添加到收藏夹

Article Multidisciplinary Sciences

Plasma metabolomic and lipidomic alterations associated with COVID-19

Di Wu et al.

NATIONAL SCIENCE REVIEW (2020)

添加到收藏夹

Article Medicine, General & Internal

Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19

Maximilian Ackermann et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Cell Biology

Omics-Driven Systems Interrogation of Metabolic Dysregulation in COVID-19 Pathogenesis

Jin-Wen Song et al.

CELL METABOLISM (2020)

添加到收藏夹

Article Medicine, Research & Experimental

COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status

Tiffany Thomas et al.

JCI INSIGHT (2020)

添加到收藏夹

Review Medicine, Research & Experimental

Unpuzzling COVID-19: tissue-related signaling pathways associated with SARS-CoV-2 infection and transmission

Daniella S. Battagello et al.

CLINICAL SCIENCE (2020)

添加到收藏夹

Article Public, Environmental & Occupational Health

What Is Analysis of Covariance (ANCOVA) and How to Correctly Report its Results in Medical Research?

Alireza KHAMMAR et al.

Iranian Journal of Public Health (2020)

添加到收藏夹

Article Biochemical Research Methods

Integrative Modeling of Quantitative Plasma Lipoprotein, Metabolic, and Amino Acid Data Reveals a Multiorgan Pathological Signature of SARS-CoV-2 Infection

Torben Kimhofer et al.

JOURNAL OF PROTEOME RESEARCH (2020)

添加到收藏夹

Article Multidisciplinary Sciences

The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism

H. Blasco et al.

SCIENTIFIC REPORTS (2020)

添加到收藏夹

Review Medicine, General & Internal

Cytokine Storm

David C. Fajgenbaum et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

添加到收藏夹

Article Endocrinology & Metabolism

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): An overview of viral structure and host response

Indwiani Astuti et al.

DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS (2020)

添加到收藏夹

Review Nutrition & Dietetics

Beta-Aminoisobutyric Acid as a Novel Regulator of Carbohydrate and Lipid Metabolism

Dmitrii A. Tanianskii et al.

NUTRIENTS (2019)

添加到收藏夹

Article Physiology

Acute Aerobic Exercise Leads to Increased Plasma Levels of R- and S-β-Aminoisobutyric Acid in Humans

Jan Stautemas et al.

FRONTIERS IN PHYSIOLOGY (2019)

添加到收藏夹

Article Chemistry, Analytical

Robust Method for High-Throughput Screening of Fatty Acids by Multisegment Injection-Nonaqueous Capillary Electrophoresis-Mass Spectrometry with Stringent Quality Control

Sandi Azab et al.

ANALYTICAL CHEMISTRY (2019)

添加到收藏夹

Editorial Material Cardiac & Cardiovascular Systems

Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and homoarginine (hArg): the ADMA, SDMA and hArg paradoxes

Dimitrios Tsikas et al.

CARDIOVASCULAR DIABETOLOGY (2018)

添加到收藏夹

Article Multidisciplinary Sciences

Diagnostic value of plasma tryptophan and symmetric dimethylarginine levels for acute kidney injury among tacrolimus-treated kidney transplant patients by targeted metabolomics analysis

Feng Zhang et al.

SCIENTIFIC REPORTS (2018)

添加到收藏夹

Article Rheumatology

Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis

Unnikrishnan M. Chandrasekharan et al.

ARTHRITIS RESEARCH & THERAPY (2018)

添加到收藏夹

Article Neurosciences

Kynurenine Pathway of Tryptophan Metabolism: Regulatory and Functional Aspects

Abdulla A-B Badawy

INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH (2017)

添加到收藏夹

Review Biochemistry & Molecular Biology

Epimetabolites: discovering metabolism beyond building and burning

Megan R. Showalter et al.

CURRENT OPINION IN CHEMICAL BIOLOGY (2017)

添加到收藏夹

Article Biochemistry & Molecular Biology

Metabolomics Workbench: An international repository for metabolomics data and metadata, metabolite standards, protocols, tutorials and training, and analysis tools

Manish Sud et al.

NUCLEIC ACIDS RESEARCH (2016)

添加到收藏夹

Article Multidisciplinary Sciences

2-Aminobutyric acid modulates glutathione homeostasis in the myocardium

Yasuhiro Irino et al.

SCIENTIFIC REPORTS (2016)

添加到收藏夹

Article Biochemical Research Methods

In-source fragmentation and correlation analysis as tools for metabolite identification exemplified with CE-TOF untargeted metabolomics

Joanna Godzien et al.

ELECTROPHORESIS (2015)

添加到收藏夹

Article Immunology

The Kynurenine Pathway of Tryptophan Catabolism, CD4+ T-Cell Recovery, and Mortality Among HIV-Infected Ugandans Initiating Antiretroviral Therapy

Helen Byakwaga et al.

JOURNAL OF INFECTIOUS DISEASES (2014)

添加到收藏夹

Article Biochemical Research Methods

Method development and validation for rat serum fingerprinting with CE-MS: application to ventilator-induced-lung-injury study

Shama Naz et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2013)

添加到收藏夹

Article Biochemical Research Methods

From numbers to a biological sense: How the strategy chosen for metabolomics data treatment may affect final results. A practical example based on urine fingerprints obtained by LC-MS

Joanna Godzien et al.

ELECTROPHORESIS (2013)

添加到收藏夹

Editorial Material Biochemistry & Molecular Biology

Trials and tribulations of 'omics data analysis: assessing quality of SIMCA-based multivariate models using examples from pulmonary medicine

Asa M. Wheelock et al.

MOLECULAR BIOSYSTEMS (2013)

添加到收藏夹

Article Oncology

The Role of Sarcosine Metabolism in Prostate Cancer Progression

Amjad P. Khan et al.

NEOPLASIA (2013)

添加到收藏夹

Article Biochemical Research Methods

Detection of glutathione in whole blood after stabilization with N-ethylmaleimide

Daniela Giustarini et al.

ANALYTICAL BIOCHEMISTRY (2011)

添加到收藏夹

Review Cell Biology

Nitric oxide and redox mechanisms in the immune response

David A. Wink et al.

JOURNAL OF LEUKOCYTE BIOLOGY (2011)

添加到收藏夹

Article Cell Biology

Tryptophan Catabolism by Indoleamine 2,3-Dioxygenase 1 Alters the Balance of TH17 to Regulatory T Cells in HIV Disease

David Favre et al.

SCIENCE TRANSLATIONAL MEDICINE (2010)

添加到收藏夹

Article Biochemistry & Molecular Biology

Update of the LIPID MAPS comprehensive classification system for lipids

Eoin Fahy et al.

JOURNAL OF LIPID RESEARCH (2009)

添加到收藏夹

Article Cardiac & Cardiovascular Systems

Differential effects of arginine methylation on diastolic dysfunction and disease progression in patients with chronic systolic heart failure

Wai Hong Wilson Tang et al.

EUROPEAN HEART JOURNAL (2008)

添加到收藏夹

Article Biochemistry & Molecular Biology

Interactions between Nitric Oxide and Indoleamine 2,3-dioxygenase

Ben J. Samelson-Jones et al.

BIOCHEMISTRY (2006)

添加到收藏夹

Article Biochemistry & Molecular Biology

Differential metabolomics reveals ophthalmic acid as an oxidative stress biomarker indicating hepatic glutathione consumption

Tomoyoshi Soga et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

添加到收藏夹

Article Medical Laboratory Technology

METLIN - A metabolite mass spectral database

CA Smith et al.

THERAPEUTIC DRUG MONITORING (2005)

添加到收藏夹

Article Biochemical Research Methods

Capillary electrophoresis of glutathione to monitor oxidative stress and response to antioxidant treatments in an animal model

N Maeso et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2005)

添加到收藏夹

Article Immunology

Nitric oxide-mediated regulation of gamma interferon-induced bacteriostasis:: inhibition and degradation of human indoleamine 2,3-dioxygenase

C Hucke et al.

INFECTION AND IMMUNITY (2004)

添加到收藏夹

Article Nutrition & Dietetics

Asymmetric dimethylarginine, and endogenous inhibitor of nitric oxide synthase, explains the L-arginine paradox and acts as a novel cardiovascular risk factor

RH Böger

JOURNAL OF NUTRITION (2004)

添加到收藏夹

Article Biochemistry & Molecular Biology

KEGG: Kyoto Encyclopedia of Genes and Genomes

M Kanehisa et al.

NUCLEIC ACIDS RESEARCH (2000)

添加到收藏夹

© Peeref 2019-2024. All rights reserved.