Individualized PID tuning for maintenance of general anesthesia with propofol and remifentanil coadministration

In this paper we propose a methodology for a patient-individualized tuning of the parameters of a proportional-integral-derivative (PID) controller that regulates the depth of hypnosis in the maintenance phase of general anesthesia. In particular, we consider a PID controller employed in a closed-loop multiple-input-single-output (MISO) control system for propofol and remifentanil coadministration. Simulation results show that the approach provides an increased robustness with respect to both intra-patient and inter-patient compared to a population-based tuning. This is obtained at the cost of a slight decrement of the controller bandwidth that causes a minor increment of the time required to reject disturbances. (C) 2021 Elsevier Ltd. All rights reserved.

Automated summary

This study proposes a methodology for patient-individualized tuning of a PID controller in general anesthesia, showing increased robustness with a slight increment in disturbance rejection time compared to population-based tuning.