期刊
IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA
卷 36, 期 1, 页码 25-+出版社
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.iac.2015.08.006
关键词
Epicutaneous allergy immunotherapy; Transcutaneous allergy immunotherapy; Respiratory allergy; Food allergy
Current allergy immunotherapy protocols suffer from two main problems: long treatment duration and systemic allergic side effects of the allergen administrations. The immunologic effects of allergen administration could be enhanced and the number of allergen administrations and treatment duration reduced by choosing a tissue for administration that contains a high density of antigen-presenting cells. Local side effects could be reduced by choosing a route characterized by a low density of mast cells, and systemic side effects could be reduced by administration to nonvascularized tissues, so that inadvertent systemic distribution of the allergen and consequent systemic allergic side effects are minimized.
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