Design and manufacturing a tubular structures based on poly(e-caprolactone) / poly(glycerol-sebacic acid) biodegradable nanocomposite blends: suggested for applications in the nervous, vascular and renal tissue engineering

The application of green-approach synthesized biopolymers for using in tissue engineering fields has grabbed much of scientific attentions in the last decade. The main cause behind this attention is related to the biocompatibility and biodegradability of these new synthesized materials. One of the most indispensable challenge in tissue engineering problems is the development of a new substrates, possessing similar morphological structures to natural extracellular matrices. In this research, an innovative tubular bionanocomposite blends based on the elastomeric polyester of poly (glycerol sebacate) (PGS) and poly caprolactone (PCL) containing nanoclay or graphene oxide (GO) are produced and used in soft tissue engineering applications. FESEM images show that the incorporation of nanoparticles dictates ordered porous texture within bionanocomposite blends. Besides, exfoliated morphology regarding blends containing GO and nanoclay is observed by XRD results. The incorporation of GO into PCL/PGS blends, besides the increment of storage modulus, increases the value of Tg from -25 degrees C (PCL/PGS blend) to -17 degrees C. Moreover, a contact angle value of 53 degrees is determined for this sample. Furthermore, the cellular adhesion and proliferation of PCL/PGS blend containing nanoclay or GO are even comparable to that of the culture plate, exhibiting their biocompatibility and potential application in the biomedical area.

Automated summary

The application of green-approach synthesized biopolymers in tissue engineering fields has gained significant attention due to their biocompatibility and biodegradability. This research focuses on the development of a new substrate with similar morphological structures to natural extracellular matrices. The innovative tubular bionanocomposite blends based on PGS and PCL, containing nanoclay or GO, show ordered porous texture and exfoliated morphology. The inclusion of GO improves storage modulus and increases Tg value, while maintaining good biocompatibility and potential application in the biomedical area.