期刊
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
卷 75, 期 3, 页码 1034-1040出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.bjps.2021.11.025
关键词
Carpal tunnel syndrome; UK Biobank; Diabetes; Rheumatoid arthritis; Hypothyroidism; BMI; Reproducibility
类别
资金
- NIHR Clinical Lecturer [MR/N001524/1]
- Wellcome Senior Clinical Scientist [202747/Z/16/Z]
- Wellcome Trust Clinical Career Development Fellowship [222101/Z/20/Z]
- National Institute for Health Research (NIHR) Oxford Biomedical Research Centre (BRC)
- NIHR
- MRC Clinical Research Training Fellowship
- Wellcome Trust [222101/Z/20/Z] Funding Source: Wellcome Trust
This study utilized the UK Biobank resource to investigate factors associated with carpal tunnel syndrome (CTS), and found that female sex, high BMI, and certain systemic diseases are associated with CTS.
Introduction: Several phenotypic factors are associated in the literature with an increased risk of carpal tunnel syndrome (CTS). Along with female sex and older age, certain systemic diseases show an association with CTS, with varying degrees of evidence. Methods: This study was performed using the UK Biobank resource - a cohort study of over 500,000 participants who have allowed linkage of phenotypic data with their medical records. We calculated the prevalence of CTS and a sex-specific prevalence ratio and compared the body mass index (BMI) between cases and controls. We performed a series of nested case-control studies to compute odds ratios for the association between CTS and three systemic diseases. Results: There were 12,312 CTS cases within the curated UK Biobank dataset of 401,656 (3.1% prevalence), and the female:male ratio was 1.95:1. CTS cases had, on average, a BMI > 2.0 kg/m2 greater than controls. Odds ratios for the association with CTS for three systemic diseases were 2.31 (95% CI 2.17-2.46) for diabetes, 2.70 (95% CI 2.44-2.99) for rheumatoid arthritis, and 1.47 (95% CI 1.38-1.57) for hypothyroidism. Adjusted for BMI, these odds ratios fell to 1.75 (95% CI 1.65-1.86), 2.43 (95% CI 2.20-2.69), and 1.35 (95% CI 1.26-1.43), respectively. Discussion: We harnessed the size and power of UK Biobank to provide robust replication of evidence for the associations between CTS and female sex, raised BMI, and three systemic diseases, which are only mediated in part by raised BMI. (c) 2021 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by El-sevier Ltd. All rights reserved.
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