期刊
IMMUNOLOGY
卷 150, 期 3, 页码 248-264出版社
WILEY
DOI: 10.1111/imm.12684
关键词
expression; haplotypes; killer-cell immunoglobulin-like receptors; ligands; natural killer cell; polymorphism
类别
资金
- French National Research Agency (ANR) [NKIR-ANR-13-PDOC-0025-01]
- U.S. National Institutes of Health [R01 AI17892]
- European Research Council (ERC)
- Medical Research Council (MRC)
Killer-cell immunoglobulin-like receptors (KIRs) are components of two fundamental biological systems essential for human health and survival. First, they contribute to host immune responses, both innate and adaptive, through their expression by natural killer cells and T cells. Second, KIR play a key role in regulating placentation, and hence reproductive success. Analogous to the diversity of their human leucocyte antigen class I ligands, KIR are extremely polymorphic. In this review, we describe recent developments, fuelled by methodological advances, that are helping to decipher the KIR system in terms of haplotypes, polymorphisms, expression patterns and their ligand interactions. These developments are delivering deeper insight into the relevance of KIR in immune system function, evolution and disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据