期刊
JOURNAL OF PHYSIOLOGICAL SCIENCES
卷 71, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12576-021-00820-2
关键词
Adipose tissue macrophages; Age; Insulin resistance
类别
In inflammaging, chronic low-grade inflammation is a characteristic of aging, which is also associated with visceral adiposity and insulin resistance. Adipose tissue macrophages (ATMs) play a significant role in obesity-related inflammation and insulin resistance. Research on the changes and functions of ATMs in aging and aging-related diseases is ongoing, with a focus on potential therapeutic targets for prevention and treatment.
Inflammaging refers to the chronic, low-grade inflammation that characterizes aging. Aging, like obesity, is associated with visceral adiposity and insulin resistance. Adipose tissue macrophages (ATMs) have played a major role in obesity-associated inflammation and insulin resistance. Macrophages are elevated in adipose tissue in aging. However, the changes and also possibly functions of ATMs in aging and aging-related diseases are unclear. In this review, we will summarize recent advances in research on the role of adipose tissue macrophages with aging-associated insulin resistance and discuss their potential therapeutic targets for preventing and treating aging and aging-related diseases.
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