Adipose tissue macrophages in aging-associated adipose tissue function

Inflammaging refers to the chronic, low-grade inflammation that characterizes aging. Aging, like obesity, is associated with visceral adiposity and insulin resistance. Adipose tissue macrophages (ATMs) have played a major role in obesity-associated inflammation and insulin resistance. Macrophages are elevated in adipose tissue in aging. However, the changes and also possibly functions of ATMs in aging and aging-related diseases are unclear. In this review, we will summarize recent advances in research on the role of adipose tissue macrophages with aging-associated insulin resistance and discuss their potential therapeutic targets for preventing and treating aging and aging-related diseases.

Automated summary

In inflammaging, chronic low-grade inflammation is a characteristic of aging, which is also associated with visceral adiposity and insulin resistance. Adipose tissue macrophages (ATMs) play a significant role in obesity-related inflammation and insulin resistance. Research on the changes and functions of ATMs in aging and aging-related diseases is ongoing, with a focus on potential therapeutic targets for prevention and treatment.