期刊
IMMUNOLOGICAL REVIEWS
卷 274, 期 1, 页码 152-171出版社
WILEY
DOI: 10.1111/imr.12475
关键词
complement receptors; factor H; host recognition; soluble regulators
类别
资金
- Deutsche Forschungsgesellschaft [SCHM 3018/2-1]
- U.S. National Institutes of Health [AI030040, AI068730]
- National Science Foundation [1423304]
- European Community's Seventh Framework Programme [602699]
- Division of Computing and Communication Foundations
- Direct For Computer & Info Scie & Enginr [1423304] Funding Source: National Science Foundation
The complement cascade is an ancient immune-surveillance system that not only provides protection from pathogen invasion but has also evolved to participate in physiological processes to maintain tissue homeostasis. The alternative pathway (AP) of complement activation is the evolutionarily oldest part of this innate immune cascade. It is unique in that it is continuously activated at a low level and arbitrarily probes foreign, modified-self, and also unaltered self-structures. This indiscriminate activation necessitates the presence of preformed regulators on autologous surfaces to spare self-cells from the undirected nature of AP activation. Although the other two canonical complement activation routes, the classical and lectin pathways, initiate the cascade more specifically through pattern recognition, their activity still needs to be tightly controlled to avoid excessive reactivity. It is the perpetual duty of complement regulators to protect the self from damage inflicted by inadequate complement activation. Here, we review the role of complement regulators as preformed mediators of defense, explain their common and specialized functions, and discuss selected cases in which alterations in complement regulators lead to disease. Finally, rational engineering approaches using natural complement inhibitors as potential therapeutics are highlighted.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据