期刊
IMMUNOLOGICAL REVIEWS
卷 274, 期 1, 页码 191-201出版社
WILEY
DOI: 10.1111/imr.12477
关键词
complementinflammation; infection; kidney
类别
资金
- Alexion Pharmaceuticals
- Achillion Pharmaceuticals
- Kidney Research UK [TF14/2015] Funding Source: researchfish
The role of the complement factor H-related (FHR) proteins in homeostasis, pathogen defense, and autoimmune disease has recently attracted considerable interest. We highlight the exciting research that has contributed to our understanding of the FHR protein family. Unlike factor H, a potent negative regulator of complement C3 activation, the FHR proteins appear to promote C3 activation. These data have important implications for understanding complement-mediated diseases because, depending on the context, the balance between the actions of factor H and the FHR proteins determines the degree of complement activation.
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