4.8 Article

Multivalency-Induced Shape Deformation of Nanoscale Lipid Vesicles: Size-Dependent Membrane Bending Effects

期刊

JOURNAL OF PHYSICAL CHEMISTRY LETTERS
卷 13, 期 6, 页码 1480-1488

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.2c00090

关键词

-

资金

  1. National Research Foundation of Korea (NRF) - Korean government (MSIT) [2020R1C1C1004385, 2021R1A4A1032782]
  2. National Research Foundation of Korea [2021R1A4A1032782] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

The size of ligand-modified lipid vesicles has a significant impact on their membrane bending properties, with a pronounced transition between 60 and 180 nm in diameter. These findings enhance our understanding of how nanoparticle size affects multivalent-induced shape deformation and can guide the design of biomimetic nanoparticles with tailored nanomechanical properties.
The size of membrane-enveloped virus particles, exosomes, and lipid vesicles strongly impacts functional properties in biological and applied contexts. Multivalent ligand-receptor interactions involving nanoparticle shape deformation are critical to such functions, yet the corresponding effect of nanoparticle size remains largely elusive. Herein, using an indirect nanoplasmonic sensing approach, we investigated how the nanoscale size properties of ligand-modified lipid vesicles affect real-time binding interactions, especially vesicle deformation processes, with a receptor-modified, cell membrane-mimicking platform. Together with theoretical analyses, our findings reveal a pronounced, size-dependent transition in the membrane bending properties of nanoscale lipid vesicles between 60 and 180 nm in diameter. For smaller vesicles, a large membrane bending energy enhanced vesicle stiffness while the osmotic pressure energy was the dominant modulating factor for larger, less stiff vesicles. These findings advance our fundamental understanding of how nanoparticle size affects multivalency-induced nanoparticle shape deformation and can provide guidance for the design of biomimetic nanoparticles with tailored nanomechanical properties.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.8
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据