期刊
IMMUNOGENETICS
卷 68, 期 8, 页码 677-691出版社
SPRINGER
DOI: 10.1007/s00251-016-0932-z
关键词
Non-classical T cells; Infectious diseases; MHC class Ib; NKT and MAIT cells
资金
- National Institutes of Health [RO1 AI46709, F31 AI124556]
- AAI Careers in Immunology Fellowship
Even though major histocompatibility complex (MHC) class Ia and many Ib molecules have similarities in structure, MHC class Ib molecules tend to have more specialized functions, which include the presentation of non-peptidic antigens to non-classical T cells. Likewise, non-classical T cells also have unique characteristics, including an innate-like phenotype in na < ve animals and rapid effector functions. In this review, we discuss the role of MAIT and NKT cells during infection but also the contribution of less studied MHC class Ib-restricted T cells such as Qa-1-, Qa-2-, and M3-restricted T cells. We focus on describing the types of antigens presented to non-classical T cells, their response and cytokine profile following infection, as well as the overall impact of these T cells to the immune system.
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