期刊
IMMUNOGENETICS
卷 68, 期 8, 页码 577-596出版社
SPRINGER
DOI: 10.1007/s00251-016-0942-x
关键词
CD1; Lipid antigens; T cell receptor; A' roof; Autoreactivity; Donor-unrestricted T cells
资金
- Bill and Melinda Gates Foundation
- Tuberculosis Research Unit Network (TBRU-N) [AI049313, AI111224, AR048632, AI115358]
The CD1 and MHC systems are specialized for lipid and peptide display, respectively. Here, we review evidence showing how cellular CD1a, CD1b, CD1c, and CD1d proteins capture and display many cellular lipids to T cell receptors (TCRs). Increasing evidence shows that CD1-reactive T cells operate outside two classical immunogenetic concepts derived from the MHC paradigm. First, because CD1 proteins are non-polymorphic in human populations, T cell responses are not restricted to the donor's genetic background. Second, the simplified population genetics of CD1 antigen-presenting molecules can lead to simplified patterns of TCR usage. As contrasted with donor-restricted patterns of MHC-TCR interaction, the donor-unrestricted nature of CD1-TCR interactions raises the prospect that lipid agonists and antagonists of T cells could be developed.
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