期刊
JOURNAL OF PHYSICAL CHEMISTRY B
卷 125, 期 50, 页码 13599-13609出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpcb.1c04873
关键词
-
资金
- National Science Foundation [CBET-1743432, OAC-1931430]
Peptide coassembly is an attractive approach for generating functional biomaterials, in which the design of peptide interactions to form nanostructures is crucial for resisting self-assembly. Recent analyses reveal that preconceived notions of structure and molecular organization may not always be correct.
Peptide coassembly, wherein at least two different peptides interact to form multicomponent nanostructures, is an attractive approach for generating functional biomaterials. Current efforts seek to design pairs of peptides, A and B, that form nanostructures (e.g., beta-sheets with ABABA-type beta-strand patterning) while resisting self-assembly (e.g., AAAAA-type or BBBBB-type beta-sheets). To confer coassembly behavior, most existing designs have been based on highly charged variants of known self-assembling peptides; like-charge repulsion limits self-assembly while opposite-charge attraction promotes coassembly. Recent analyses using solid-state NMR and coarse-grained simulations reveal that preconceived notions of structure and molecular organization are not always correct. This perspective highlights recent advances and key challenges to understanding and controlling peptide coassembly.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据