Assessing the Utility of In-Line Intravenous Infusion Filters

The use of in-line filters to remove fibrous material in the administration of intravenous fluids dates to the early 1830's. Following advancements in therapeutic interventions, high volume fluid support and parenter-ally administered drugs and biologic preparations, some observers are calling for a routine use of bedside fil-tration. Unfortunately, the assessment of filter components, their interaction and compatibility with the drug product, and the impact of use on clinical outcomes cannot be conducted by a single entity. Recommenda-tions for use are often predicated upon fragmented and incomplete information. The current challenges in evaluating the benefit/risk profile for the use of in-line filters should not be ignored. While there are select instances showing well-defined therapeutic settings where in-line filtration of intravenous infusions would likely provide an additional safety margin and hence, net benefit, the majority of observational studies to date fail to provide sufficient scientific support for broad-based routine use. While infusion set filters are appropriate where expert opinion is well corroborated by scientific evidence, the general and routine use of filters used during parenteral administration cannot be supported by substantive studies and should not be routinely utilized. Ultimately, the determination falls to a healthcare provider with the information available at-hand. (c) 2021 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.

Automated summary

The use of in-line filters in intravenous fluid administration dates back to the early 1830s, but assessing the filter components, their interactions with drug products, and the impact on clinical outcomes remains a challenge. While some well-defined therapeutic settings may benefit from in-line filtration, the majority of observational studies do not provide enough scientific support for broad-based routine use. Ultimately, the decision on filter use falls on healthcare providers based on available information.