4.7 Article

Local factor H production by human choroidal endothelial cells mitigates complement deposition: implications for macular degeneration

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Genetics & Heredity

Beyond factor H: The impact of genetic-risk variants for age-related macular degeneration on circulating factor-H-like 1 and factor-H-related protein concentrations

Valentina Cipriani et al.

Summary: The study revealed that mutations at the complement factor H (CFH) locus may lead to elevated concentrations of circulating FHR proteins, which could be major drivers of AMD. These findings support the need for research into FHR protein modulation as a potential therapeutic avenue for AMD.

AMERICAN JOURNAL OF HUMAN GENETICS (2021)

Article Genetics & Heredity

Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular degeneration

Laura Lores-Motta et al.

Summary: FHR proteins were identified as key players in the AMD disease mechanism, suggesting that therapies targeting specific individuals with AMD based on their genotypes at the CFH locus could be effective.

AMERICAN JOURNAL OF HUMAN GENETICS (2021)

Article Biochemistry & Molecular Biology

CFH Loss in Human RPE Cells Leads to Inflammation and Complement System Dysregulation via the NF-κB Pathway

Angela Armento et al.

Summary: AMD, the leading cause of vision loss in elderly, has a strong genetic association with the CFH gene polymorphism. Endogenous CFH in RPE cells modulates inflammatory cytokine production and complement regulation, with the NF-kappa B pathway playing a major role in regulating these factors.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Article Ophthalmology

Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration

John T. Demirs et al.

Summary: The dysregulation of the alternative complement pathway is a major pathogenic mechanism in age-related macular degeneration. Complement mRNA and protein expression levels were found to be significantly higher in macular retinal pigment epithelium/choroid tissue than in the neural retina, regardless of AMD grade status. The study suggests that the RPE/choroid is the primary site for complement inhibition to treat geographic atrophy or earlier stages of the disease.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2021)

Article Ophthalmology

Spectacle: An interactive resource for ocular single-cell RNA sequencing data analysis

Andrew P. Voigt et al.

EXPERIMENTAL EYE RESEARCH (2020)

Article Pathology

Choriocapillaris Degeneration in Geographic Atrophy

Elliott H. Sohn et al.

AMERICAN JOURNAL OF PATHOLOGY (2019)

Article Peripheral Vascular Disease

Generation of an immortalized human choroid endothelial cell line (iChEC-1) using an endothelial cell specific promoter

Joseph C. Giacalone et al.

MICROVASCULAR RESEARCH (2019)

Article Multidisciplinary Sciences

Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration

Andrew P. Voigt et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Ophthalmology

Retinal Macrophages Synthesize C3 and Activate Complement in AMD and in Models of Focal Retinal Degeneration

Riccardo Natoli et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2017)

Article Ophthalmology

Selective accumulation of the complement membrane attack complex in aging choriocapillaris

Kathleen R. Chirco et al.

EXPERIMENTAL EYE RESEARCH (2016)

Review Genetics & Heredity

AMD and the alternative complement pathway: genetics and functional implications

Perciliz L. Tan et al.

HUMAN GENOMICS (2016)

Article Ophthalmology

Albumen Transport to Bruch's Membrane and RPE by Choriocapillaris Caveolae

Masataka Nakanishi et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2016)

Review Biochemistry & Molecular Biology

Age-related macular degeneration and the role of the complement system

Selina McHarg et al.

MOLECULAR IMMUNOLOGY (2015)

Article Ophthalmology

Complement activation and choriocapillaris loss in early AMD: Implications for pathophysiology and therapy

S. Scott Whitmore et al.

PROGRESS IN RETINAL AND EYE RESEARCH (2015)

Article Ophthalmology

C-reactive protein and complement factor H in aged human eyes and eyes with age-related macular degeneration

Imran A. Bhutto et al.

BRITISH JOURNAL OF OPHTHALMOLOGY (2011)

Article Ophthalmology

Elevated membrane attack complex in human choroid with high risk complement factor H genotypes

Robert F. Mullins et al.

EXPERIMENTAL EYE RESEARCH (2011)

Article Multidisciplinary Sciences

Complement factor H binds malondialdehyde epitopes and protects from oxidative stress

David Weismann et al.

NATURE (2011)

Article Ophthalmology

Choriocapillaris Vascular Dropout Related to Density of Drusen in Human Eyes with Early Age-Related Macular Degeneration

Robert E. Mullins et al.

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2011)

Review Immunology

Complement: a key system for immune surveillance and homeostasis

Daniel Ricklin et al.

NATURE IMMUNOLOGY (2010)

Article Biochemistry & Molecular Biology

Oxidative Stress Renders Retinal Pigment Epithelial Cells Susceptible to Complement-mediated Injury

Joshua M. Thurman et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Review Medicine, General & Internal

MEDICAL PROGRESS Atypical Hemolytic-Uremic Syndrome

Marina Noris et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Biochemistry & Molecular Biology

Modified low density lipoproteins differentially bind and activate the C1 complex of complement

Adrienn Biro et al.

MOLECULAR IMMUNOLOGY (2007)

Article Multidisciplinary Sciences

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

GS Hageman et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Multidisciplinary Sciences

Complement factor H polymorphism in age-related macular degeneration

RJ Klein et al.

SCIENCE (2005)

Article Multidisciplinary Sciences

Complement factor H polymorphism and age-related macular degeneration

AO Edwards et al.

SCIENCE (2005)

Article Multidisciplinary Sciences

Complement factor H variant increases the risk of age-related macular degeneration

JL Haines et al.

SCIENCE (2005)

Article Ophthalmology

Posterior ciliary artery circulation in health and disease - The Weisenfeld Lecture

SS Hayreh

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE (2004)