期刊
IMMUNITY
卷 45, 期 3, 页码 583-596出版社
CELL PRESS
DOI: 10.1016/j.immuni.2016.08.002
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类别
资金
- HHMI
- NIH [AI054359]
- MMPC NIH [DK059635]
- Pilot and Feasibility Project Grants from Diabetes Research Center at Yale
Mononuclear phagocytes (MNPs) are a highly heterogeneous group of cells that play important roles in maintaining the body's homeostasis. Here, we found CD301b (also known as MGL2), a lectin commonly used as a marker for alternatively activated macrophages, was selectively expressed by a subset of CD11b(+) CD11c(+) MHCII+ MNPs in multiple organs including adipose tissues. Depleting CD301b(+) MNPs in vivo led to a significant weight loss with increased insulin sensitivity and a marked reduction in serum Resistin-like molecule (RELM) a, a multifunctional cytokine produced by MNPs. Reconstituting RELM alpha in CD301b(+) MNP-depleted animals restored body weight and normoglycemia. Thus, CD301b(+) MNPs play crucial roles in maintaining glucose metabolism and net energy balance.
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