[4+1+1] Tandem Cyclization Reaction Involving Isocyanides: Access to 2-(Trifluoromethyl)quinazolin-4(3H)-imines

A palladium-catalyzed three-component reaction of isocyanides, 2,2,2-trifluoro-N-(2-iodophenyl)acetimidoyl chlorides, and amines for the one-pot synthesis of 2-(trifluoromethyl)-quinazolin-4(3H)-imines was described. The protocol features a wide substrate scope, high efficiency, and readily available raw materials.

Automated summary

A palladium-catalyzed three-component reaction was used for the one-pot synthesis of 2-(trifluoromethyl)-quinazolin-4(3H)-imines, using isocyanides, 2,2,2-trifluoro-N-(2-iodophenyl)acetimidoyl chlorides, and amines. The protocol offers a wide substrate scope, high efficiency, and readily available raw materials.