Anodic C(sp3)-H Acyloxylation of Indolin-3-ones Enabled by Oxidant-Free Cross-Dehydrogenative C(sp3)-O Coupling

An efficient anodic C(sp(3))-H acyloxylation protocol has been established via intermolecular cross-dehydrogenative C(sp(3))-O coupling. The protocol provides various C2-acyloxy indolin-3-ones without the addition of metal catalysts and external oxidants because indolin-3-ones can be directly oxidized at the anode. The effective application of several medical drugs and the realization of the gram-scale experiment have proven the practicality of this protocol.

Automated summary

An efficient anodic C(sp(3))-H acyloxylation protocol has been developed, which enables the direct oxidation of indolin-3-ones to obtain various C2-acyloxy indolin-3-ones without the need for metal catalysts and external oxidants. The practicality of this protocol has been demonstrated through the effective application of several medical drugs and gram-scale experiments.