Visible-Light-Induced Multicomponent Cascade Cycloaddition of N-Propargyl Aromatic Amines, Cyclobutanone Oxime Esters, and K2S2O5: Access to Cyanoalkylsulfonylated Quinolines

A visible-light-induced cascade cyanoalkylsulfonylation/cyclization/aromatization of N-propargyl aromatic amines with K2S2O5 and cyclobutanone oxime esters for the construction of cyanoalkylsulfonylated quinolines is developed. This cascade transformation features mild reaction conditions, a broad substrate scope, and excellent functional group compatibility, providing a convenient route toward cyanoalkylsulfonylated quinolines via the formation of a C-C bond and two C-S bonds in one step.

Automated summary

A visible-light-induced cascade cyanoalkylsulfonylation/cyclization/aromatization reaction has been developed for the construction of cyanoalkylsulfonylated quinolines, with mild reaction conditions, broad substrate scope, and excellent functional group compatibility. This cascade transformation provides a convenient route towards cyanoalkylsulfonylated quinolines by forming a C-C bond and two C-S bonds in one step.