期刊
JOURNAL OF ORGANIC CHEMISTRY
卷 86, 期 24, 页码 17965-17974出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c02300
关键词
-
资金
- SERB, New Delhi [EMR/2016/006358]
- Indian Institute of Science
- DYNARX Pvt. Ltd.
- SYNMR Chemicals Pvt. Ltd.
- CSIR, New Delhi
A regioselective synthesis of furanone-fused isoquinoline heterocycles was achieved in a single step using a Rh(III) catalyst, showing good regioselectivity with a wide range of alkynoates. The regioselectivity was guided by steric bulk at the C4 position of the 4-hydroxy-2-alkynoates. The synthetic utility was demonstrated with a model reaction scaled up to 1 g.
A regioselective synthesis of furanone-fused isoquinoline heterocycles is developed in a single step using a Rh(III) catalyst. In this reaction, a cascade C-H activation, regioselective annulation, and lactonization occur in one pot. A wide range of alkynoates was examined, which showed good regioselectivity. The regioselectivity was guided by steric bulk at the C4 position of the 4-hydroxy-2-alkynoates. The synthetic utility was exemplified, and the model reaction was scaled up to a 1 g scale.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据