4.7 Article

Electro-Oxidative sp(3) C-H Bond Functionalization and Annulation Cascade: Synthesis of Novel Heterocyclic Substituted Indolizines

期刊

JOURNAL OF ORGANIC CHEMISTRY
卷 87, 期 5, 页码 2898-2911

出版社

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c02773

关键词

-

资金

  1. SERB, India [SRG/2020/000721]

向作者/读者索取更多资源

This study reports a novel electro-oxidative cascade cyclization reaction, using electricity as the primary energy input, to synthesize a series of indolizine derivatives. This method provides a new strategy for generating heterocyclic diversity of indolizines.
Indolizine derivatives are prevalent in many synthetic intermediates, pharmaceuticals, and organic materials. Herein, we report a novel electro-oxidative cascade cyclization reaction that uses electricity as the primary energy input to promote the reaction, leading to a series of heterocyclic substituted indolizine derivatives under exogenous-oxidant-free conditions. It is noteworthy that this electrochemical method provides a novel strategy for generating heterocyclic diversity of quinazolinones and quinolines on indolizines. In addition, the sole byproduct in the reaction was molecular hydrogen.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据